Objectives

Family history of stroke increases stroke risk, however mechanisms underlying this association remain unclear. We investigated whether family history of stroke is related to increased prevalence of stroke risk factors, unhealthy behaviors and self-reported stroke symptoms in middle-aged adults.

Materials and Methods

In a cross-sectional study conducted from November 2018 to January 2021 in 100 primary care facilities in Poland we evaluated adults aged 40-65 years (n = 2207, women 57.4%, median age 55 years) for stroke risk factors, healthy behaviors, family history of stroke, self-reported stroke symptoms and stroke knowledge using structured questionnaires. Patients were categorized based on family history of stroke defined as ≥1 first-degree relative with documented stroke.

Results

Family history of stroke was reported by 571 (25.9%) individuals who were older (median age 56 vs. 54 years, p = 0.00001) and after adjustment for age more frequently suffered from hypertension (61.5% vs. 53.7%, p = 0.024) and prior transient ischemic attack (2.1% vs. 0.9%, p = 0.019), but not other risk factors. However, they were less obese (34.5% vs. 39.1%, p = 0.03). Women, but not men, with family history of stroke (n = 339, 26.8%) had greater prevalence of atrial fibrillation (7.4% vs. 3.9%, p = 0.037). Family history of stroke was associated with higher prevalence of any self-reported stroke symptom (32.9% vs. 23.2%, p < 0.00001), but not with unhealthy dietary behaviors or low level of knowledge about stroke.

Conclusions

Family history of stroke is associated with greater prevalence of certain risk factors and self-reported stroke symptoms, which indicates the need for closer surveillance of middle-aged individuals at risk.

中文翻译：

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中风家族史与某些危险因素的患病率和自我报告的中风症状有关

目标

卒中家族史会增加卒中风险，但这种关联背后的机制仍不清楚。我们调查了中风家族史是否与中年成人中风危险因素、不健康行为和自我报告的中风症状的患病率增加有关。

材料和方法

在 2018 年 11 月至 2021 年 1 月在波兰 100 家初级保健机构进行的一项横断面研究中，我们评估了 40-65 岁的成年人（n  = 2207，女性 57.4%，中位年龄 55 岁）的中风危险因素、健康行为、使用结构化问卷调查卒中家族史、自我报告的卒中症状和卒中知识。根据卒中家族史对患者进行分类，卒中家族史定义为≥1 名有卒中记录的一级亲属。

结果

571 名 (25.9%) 年龄较大的个体（中位年龄 56 岁 vs. 54 岁， p = 0.00001）报告了卒中家族史， 并且在调整年龄后更频繁地患有高血压（61.5% vs. 53.7%，p  = 0.024 ) 和先前的短暂性脑缺血发作 (2.1% vs. 0.9%, p  = 0.019)，但没有其他风险因素。然而，他们的肥胖程度较低（34.5% 对 39.1%，p  = 0.03）。有卒中家族史的女性（而不是男性）（n  = 339, 26.8%）的房颤患病率更高（7.4% vs. 3.9%, p  = 0.037）。卒中家族史与任何自我报告的卒中症状的患病率较高相关（32.9% vs. 23.2%，p < 0.00001），但与不健康的饮食行为或中风知识水平低无关。

结论

卒中家族史与某些危险因素和自我报告的卒中症状的患病率较高相关，这表明需要对有风险的中年人进行更密切的监测。