Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2021-08-28 , DOI: 10.1016/j.jneuroim.2021.577704 Zahra Pourmoghaddas 1 , Atefeh Sadeghizadeh 2 , Seyedeh Zahra Tara 3 , Alireza Zandifar 4 , Hamid Rahimi 1 , Rana Saleh 5 , Mohammadreza Ghazavi 6 , Omid Yaghini 6 , Neda Hosseini 6 , Niloofar Javadi 7 , Mohammad Saadatnia 8 , Arastoo Vossough 4
COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated with paralysis of the extremities. MRI showed abnormal signal in the cervical spinal cord compatible with transverse myelitis. Methylprednisolone and IVIG were administered, without significant symptom improvement. As a next step, Infliximab was tried for her, and she responded remarkably well to this treatment. Infliximab may be considered as a treatment option in COVID-19 patients with transverse myelitis.
中文翻译:
纵向广泛的横贯性脊髓炎是 COVID-19 感染后多系统炎症综合征的标志:儿科病例报告
COVID-19 感染可引起炎症反应,可能涉及多个器官。在儿科人群中,据报道,儿童多系统炎症综合征 (MIS-C) 是 COVID-19 的后果之一。我们报告了一名患有 MIS-C 的独特儿科 COVID-19 患者,伴有四肢瘫痪。MRI 显示与横贯性脊髓炎相符的颈脊髓异常信号。给予甲泼尼龙和 IVIG,症状无明显改善。下一步,为她试用了英夫利昔单抗,她对这种治疗反应非常好。英夫利昔单抗可被视为 COVID-19 横贯性脊髓炎患者的一种治疗选择。