House dust mites (HDM) are considered as a major source of indoor aeroallergen all over the world that precipitate allergic reactions including rhinoconjunctivitis, food allergy, atopic dermatitis, and allergic asthma. In this study, we aimed to assess the clinical and laboratory profile of some Egyptian asthmatic children who are sensitized to house dust mites and determine the association of HDM sensitization and severity of asthma according to recent GINA guidelines. The most frequent clinical phenotype among the HDM-positive group was a cough (96.7%), while the clinical phenotypic wheeze was frequent in HDM negative group (96.7%). There is a statistically significant difference between studied cases classified according to sensitivity to HDM regarding level of asthma control (50.0% were uncontrolled among cases sensitive to HDM and 56.7% of cases non-sensitive to HDM were controlled (p = 0.001*). Severity according to treatment results was significantly higher among cases sensitive to HDM (26.7% of cases sensitive to HDM versus 3.3% of cases non-sensitive to HDM), p = 0.017. HDM sensitization is associated mainly with cough asthma phenotype and allergic rhinitis in our studied cases. HDM sensitization increases asthma severity and decreases the ability to control asthma symptoms. ClinicalTrial.gov, NCT04958616.

中文翻译：

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曼苏拉大学儿童医院儿童房尘螨致敏与哮喘控制水平和严重程度之间的关系

屋尘螨 (HDM) 在世界范围内被认为是室内空气过敏原的主要来源，可引起过敏反应，包括鼻结膜炎、食物过敏、特应性皮炎和过敏性哮喘。在本研究中，我们旨在评估一些对屋尘螨敏感的埃及哮喘儿童的临床和实验室特征，并根据最近的 GINA 指南确定 HDM 致敏性与哮喘严重程度之间的关联。HDM 阳性组中最常见的临床表型是咳嗽 (96.7%)，而 HDM 阴性组中最常见的临床表型是喘息 (96.7%)。根据对 HDM 的敏感性分类的研究病例在哮喘控制水平方面存在统计学显着差异（在对 HDM 敏感的病例和 56. 7% 对 HDM 不敏感的病例得到控制（p = 0.001*）。根据治疗结果的严重程度在对 HDM 敏感的病例中显着更高（对 HDM 敏感的病例为 26.7%，对 HDM 不敏感的病例为 3.3%），p = 0.017。在我们研究的病例中，HDM 致敏主要与咳嗽哮喘表型和过敏性鼻炎有关。HDM 致敏会增加哮喘的严重程度并降低控制哮喘症状的能力。ClinicalTrial.gov，NCT04958616。HDM 致敏会增加哮喘的严重程度并降低控制哮喘症状的能力。ClinicalTrial.gov，NCT04958616。HDM 致敏会增加哮喘的严重程度并降低控制哮喘症状的能力。ClinicalTrial.gov，NCT04958616。