Transdermal delivery of drugs is a quite challenging task for pharmaceutical scientists. The transdermal route is preferred over the oral route due to various advantages like avoidance of the first-pass effect, non-invasiveness, and high patient compliance. Therefore, it is necessary to develop an effective carrier system that enables the effective passage of the drug through the dermal barrier. Various novel drug delivery systems are used to enhance the permeation of a variety of drugs through the skin barrier. Researchers around the globe have explored nanofibers for the transdermal delivery of various therapeutic agents. Nanofibers are designed to have a high concentration of therapeutic agents in them promoting their flux through various skin layers. Polymeric nanofibers can be explored for the loading of both hydrophilic and lipophilic drugs. Biopolymer-based nanofibers have been also explored for transdermal delivery. They are capable of controlling the release of therapeutic agents for a prolonged time. The literature presented in this review paper provides significant proof that nanofibers will have an intense impact on the transdermal delivery of different bioactive molecules in the future.

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纳米纤维作为治疗药物透皮给药的新型载体：挑战与机遇

药物的透皮递送对于制药科学家来说是一项非常具有挑战性的任务。由于诸如避免首过效应、非侵入性和高患者依从性等多种优点，经皮途径优于口服途径。因此，有必要开发一种有效的载体系统，使药物能够有效地通过皮肤屏障。各种新型药物递送系统用于增强各种药物通过皮肤屏障的渗透。全球的研究人员已经探索了用于透皮递送各种治疗剂的纳米纤维。纳米纤维被设计成在其中含有高浓度的治疗剂，以促进它们通过各种皮肤层的流动。聚合物纳米纤维可用于装载亲水性和亲脂性药物。还探索了基于生物聚合物的纳米纤维用于透皮递送。它们能够长时间控制治疗剂的释放。本综述论文中的文献提供了重要的证据，证明纳米纤维未来将对不同生物活性分子的透皮递送产生强烈影响。