Alopecia refers to a condition developed by gradual reduction of hair loss by various abnormal causes such as endocrine system, genetic factors, and stress. Stromal vascular fraction (SVF) isolated from the fat is one of the latest innovative solutions in the field of regeneration therapy. We focused on presenting effectiveness of clinical cases to improve AGA through transplantation of autologous SVF into the scalp. To confirm the efficacy of the autologous SVF usage to the patients with AGA. Nine patients (age range 43–64 years; 4 men, grade IV to V and 5 women, grade I to III), who are suffering from androgenic alopecia (AGA), were treated with single transplantation of autologous SVF in the upper scalp. Autologous SVF was isolated and characterized prior to the injection of live 7–9 × 106 cells into the patients’ treatment site. The hair loss improvement effect was assessed by three test criteria: hair skin quality, hair thickness and hair density 3 and 6 months after post-injection compared to pre-injection status. Hair density of SVF-treated side was significantly increased after 3 and 6 months of transplantation compared to non-treated side (P = 0.01 and P = 0.009 per each). And significant improvement in the score of the keratin on the scalp was seen in the injected area as compared to the non-injected area 6 months after transplantation (P = 0.032). Although thickness increase was observed at 3 and 6 months after transplantation, there was no statistical significance (P = 0.142 and 0.155, respectively). One transplantation of autologous SVF for the AGA patients, hair density and score for the keratin were significantly increased within 6 months. This study shows that SVF is a very effective way to treat hair loss and most of subjects are satisfied with the result after treatment.

中文翻译：

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自体脂肪源性SVF治疗脱发的创新方法

脱发是指由于内分泌系统、遗传因素和压力等各种异常原因导致脱发逐渐减少而形成的一种病症。从脂肪中分离出的基质血管成分 (SVF) 是再生治疗领域最新的创新解决方案之一。我们重点介绍了通过将自体 SVF 移植到头皮来改善 AGA 的临床病例的有效性。确认自体 SVF 使用对 AGA 患者的疗效。9 名患有雄激素性脱发 (AGA) 的患者（年龄范围 43-64 岁；4 名男性，IV 级至 V 级和 5 名女性，I 至 III 级），接受了上头皮单次自体 SVF 移植治疗。在将 7–9 × 106 活细胞注射到患者的治疗部位之前，自体 SVF 被分离和表征。脱发改善效果通过三个测试标准来评估：与注射前状态相比，注射后3个月和6个月的毛发皮肤质量、毛发厚度和毛发密度。与未治疗侧相比，移植 3 个月和 6 个月后，SVF 治疗侧的毛发密度显着增加（每个 P = 0.01 和 P = 0.009）。与移植后6个月的非注射区域相比，注射区域的头皮角蛋白评分有显着改善（P = 0.032）。尽管在移植后 3 个月和 6 个月观察到厚度增加，但没有统计学意义（分别为 P = 0.142 和 0.155）。AGA患者移植1次自体SVF，6个月内毛发密度和角蛋白评分显着增加。