Self-reported health status as measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ) in patients with primary prevention implantable cardioverter defibrillators (ICDs) has mainly been reported from randomized trials. However, these studies are often limited to short follow-up and are subject to selection bias. The aim of this study was to assess KCCQ-12 in patients with primary prevention ICD due to either ischemic or nonischemic heart failure. This cross-sectional observational study included all patients in Region Gävleborg, Sweden, who because of primary prevention due to heart failure, had an ICD or underwent device replacement between 2007 and 2017. After validation using medical records patients were sent and returned the KCCQ-12 by regular mail. A total of 118 questionnaires were analyzed (response rate 71.1%). The mean age was 70.9 ± 9.8 years, and a minority was female (n = 20, 16.9%). The mean overall summary score was 71.5 ± 22.4, there was no significant difference between ischemic and nonischemic heart failure (69.5 ± 23.1 vs. 74.4 ± 21.3; p = 0.195). Atrial fibrillation at baseline was associated with lower score for the domains Symptom frequency (70.2 ± 23.2 vs. 82.2 ± 19.2; p = 0.006) and Social limitation (62.1 ± 26.0 vs. 75.6 ± 26.6; p = 0.006) as well as the overall summary score (63.9 ± 21.3 vs. 74.8 ± 22.2; p = 0.004). In a real-world setting, primary prevention ICD patients with heart failure report an acceptable disease-specific health status at long-term follow-up. Ischemic and nonischemic etiology showed similar health status whereas atrial fibrillation was associated with worse outcome.

中文翻译：

---

堪萨斯城心肌病问卷 12 测量的一级预防植入式心律转复除颤器心力衰竭患者的健康状况

使用堪萨斯城心肌病问卷 (KCCQ) 测量的一级预防植入式心律转复除颤器 (ICD) 患者自我报告的健康状况主要来自随机试验。然而，这些研究通常仅限于短期随访，并受到选择偏倚的影响。本研究的目的是评估 KCCQ-12 在因缺血性或非缺血性心力衰竭导致一级预防 ICD 的患者中的作用。这项横断面观察性研究包括瑞典 Gävleborg 地区的所有患者，这些患者在 2007 年至 2017 年期间因心力衰竭进行一级预防而安装了 ICD 或接受了设备更换。在使用医疗记录进行验证后，患者被发送并返回了 KCCQ- 12 通过普通邮件。共分析问卷 118 份（回收率 71.1%）。平均年龄为 70 岁。9 ± 9.8 岁，少数是女性（n = 20, 16.9%）。平均总评分为 71.5 ± 22.4，缺血性和非缺血性心力衰竭之间没有显着差异（69.5 ± 23.1 对 74.4 ± 21.3；p = 0.195）。基线时的心房颤动与症状频率（70.2 ± 23.2 对 82.2 ± 19.2；p = 0.006）和社会限制（62.1 ± 26.0 对 75.6 ± 26.6；p = 0.006）以及总体得分较低相关总分（63.9 ± 21.3 对 74.8 ± 22.2；p = 0.004）。在现实世界中，一级预防 ICD 心力衰竭患者在长期随访中报告了可接受的特定疾病健康状况。缺血性和非缺血性病因表现出相似的健康状况，而心房颤动与较差的结果相关。平均总评分为 71.5 ± 22.4，缺血性和非缺血性心力衰竭之间没有显着差异（69.5 ± 23.1 对 74.4 ± 21.3；p = 0.195）。基线时的心房颤动与症状频率（70.2 ± 23.2 对 82.2 ± 19.2；p = 0.006）和社会限制（62.1 ± 26.0 对 75.6 ± 26.6；p = 0.006）以及总体得分较低相关总分（63.9 ± 21.3 对 74.8 ± 22.2；p = 0.004）。在现实世界中，一级预防 ICD 心力衰竭患者在长期随访中报告了可接受的特定疾病健康状况。缺血性和非缺血性病因表现出相似的健康状况，而心房颤动与较差的结果相关。平均总评分为 71.5 ± 22.4，缺血性和非缺血性心力衰竭之间没有显着差异（69.5 ± 23.1 对 74.4 ± 21.3；p = 0.195）。基线时的心房颤动与症状频率（70.2 ± 23.2 对 82.2 ± 19.2；p = 0.006）和社会限制（62.1 ± 26.0 对 75.6 ± 26.6；p = 0.006）以及总体得分较低相关总分（63.9 ± 21.3 对 74.8 ± 22.2；p = 0.004）。在现实世界中，一级预防 ICD 心力衰竭患者在长期随访中报告了可接受的特定疾病健康状况。缺血性和非缺血性病因表现出相似的健康状况，而心房颤动与较差的结果相关。5 ± 23.1 与 74.4 ± 21.3；p = 0.195）。基线时的心房颤动与症状频率（70.2 ± 23.2 对 82.2 ± 19.2；p = 0.006）和社会限制（62.1 ± 26.0 对 75.6 ± 26.6；p = 0.006）以及总体得分较低相关总分（63.9 ± 21.3 对 74.8 ± 22.2；p = 0.004）。在现实世界中，一级预防 ICD 心力衰竭患者在长期随访中报告了可接受的特定疾病健康状况。缺血性和非缺血性病因表现出相似的健康状况，而心房颤动与较差的结果相关。5 ± 23.1 与 74.4 ± 21.3；p = 0.195）。基线时的心房颤动与症状频率（70.2 ± 23.2 对 82.2 ± 19.2；p = 0.006）和社会限制（62.1 ± 26.0 对 75.6 ± 26.6；p = 0.006）以及总体得分较低相关总分（63.9 ± 21.3 对 74.8 ± 22.2；p = 0.004）。在现实世界中，一级预防 ICD 心力衰竭患者在长期随访中报告了可接受的特定疾病健康状况。缺血性和非缺血性病因表现出相似的健康状况，而心房颤动与较差的结果相关。006）以及总分（63.9 ± 21.3 vs. 74.8 ± 22.2；p = 0.004）。在现实世界中，一级预防 ICD 心力衰竭患者在长期随访中报告了可接受的特定疾病健康状况。缺血性和非缺血性病因表现出相似的健康状况，而心房颤动与较差的结果相关。006）以及总分（63.9 ± 21.3 vs. 74.8 ± 22.2；p = 0.004）。在现实世界中，一级预防 ICD 心力衰竭患者在长期随访中报告了可接受的特定疾病健康状况。缺血性和非缺血性病因表现出相似的健康状况，而心房颤动与较差的结果相关。