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Carbon nanotubes for cardiac tissue regeneration: State of the art and perspectives
Carbon ( IF 10.5 ) Pub Date : 2021-08-28 , DOI: 10.1016/j.carbon.2021.08.059
Myriam Barrejón 1 , Silvia Marchesan 1 , Nuria Alegret 2 , Maurizio Prato 1, 2, 3
Affiliation  

Carbon nanotubes (CNTs) have appeared in recent years as innovative components for the development of the next-generation scaffolds to regenerate damaged cardiac tissue. The unique robustness, mechanical and electronic properties of CNTs, along with their ease to undergo chemical modification, make them promising candidates for the design of engineered cardiac constructs with ad hoc properties. The integration of CNTs with polymeric scaffolds is a promising strategy for cardiac regeneration since, as reviewed in these pages, their conductivity has a boosting effect on cardiomyocytes behavior, including their synchronous contractility when grown on top of the nanomaterial. More recently, the conductive properties of pure CNTs are attracting interest to design innovative systems based on bare CNTs without using other fillers. Additionally, the elongated CNT morphology is a strategic asset for the mimicry of the anisotropic myocardium structure, and research has made great progress over the production of micropatterned scaffolds with nanoscale definition that aim to recapitulate the cardiac tissue. Overall, engineered CNT constructs are revealing their great potential to develop new platforms able to interface, repair, or boost the performance of cardiac tissue.



中文翻译:

用于心脏组织再生的碳纳米管:最新技术和前景

近年来,碳纳米管 (CNT) 作为创新组件出现,用于开发下一代支架以再生受损的心脏组织。碳纳米管独特的坚固性、机械和电子特性,以及它们易于进行化学改性,使它们成为设计具有特殊功能的工程心脏结构的有希望的候选者。特性。碳纳米管与聚合物支架的整合是心脏再生的一种有前景的策略,因为正如这些页面中所述,它们的导电性对心肌细胞行为具有促进作用,包括它们在纳米材料顶部生长时的同步收缩性。最近,纯碳纳米管的导电特性吸引了人们对基于裸碳纳米管而不使用其他填料设计创新系统的兴趣。此外,细长的 CNT 形态是模拟各向异性心肌结构的战略资产,并且研究在生产具有纳米级定义的微图案支架方面取得了很大进展,旨在重现心脏组织。总体而言,工程化的 CNT 结构显示出它们在开发能够连接、修复、

更新日期:2021-09-02
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