Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2. Consistent with these results, DRG2 Tg mice showed increased expression of genes involved in adipogenesis and lipid metabolism in the white adipose tissue. DRG2 was also identified to control adipogenesis by cooperating with peroxisome proliferator activated receptor-γ (PPAR-γ) in cultured adipocytes. Overall, the findings of the current study suggest that DRG2 plays an active role in regulating adipocyte differentiation, and thus participates in the development of obesity during exposure to a fat-rich diet.

发育调节的 GTP 结合蛋白 2 (DRG2) 参与调节多种细胞的增殖和分化。然而，DRG2 是否调节脂肪细胞分化和相关的代谢控制仍然难以捉摸。该研究揭示了过表达 DRG2 的 DRG2 转基因 (Tg) 小鼠的体重和肥胖增加。与这些结果一致，DRG2 Tg 小鼠在白色脂肪组织中显示出参与脂肪生成和脂质代谢的基因表达增加。DRG2 还被鉴定为通过与培养的脂肪细胞中的过氧化物酶体增殖物激活受体-γ (PPAR-γ) 合作来控制脂肪生成。总体而言，目前的研究结果表明 DRG2 在调节脂肪细胞分化中发挥着积极作用，