Abstract

In this study we have developed a cisplatin drug carrier nanoparticles based on biomaterials—chitosan and lactic acid. Drug was loaded in synthesized Chitosan-co-lactic acid nanoparticles by absorption method, to investigate the drug release behavior. Nanoparticles have potential to encapsulate drug and subsequent release it in swelling controlled manner. The release profile of cisplatin from nanoparticles showed controlled release for over 3 days. It has also been observed that the drug release is highly influenced by the chemical composition, pH, temperature and physiological fluids. Several drug release model have been used to design an effective formulation and to provide the understanding of drug release profile from a therapeutic system. These nanoparticles of chitosan-co-lactic acid have been found to be promising biomaterials as controlled drug release vehicles.

摘要

在这项研究中，我们开发了一种基于生物材料——壳聚糖和乳酸的顺铂药物载体纳米颗粒。采用吸收法将药物负载于合成的壳聚糖-共-乳酸纳米粒中，研究药物释放行为。纳米颗粒具有封装药物并随后以溶胀控制方式释放药物的潜力。顺铂从纳米颗粒的释放曲线显示受控释放超过 3 天。还观察到药物释放受化学成分、pH、温度和生理液体的影响很大。几种药物释放模型已被用于设计有效的制剂并提供对治疗系统药物释放曲线的理解。