Hantaviruses are etiological agents of several severe respiratory illnesses in humans and their human-to-human transmission has been reported. To cope with any potential pandemic, this group of viruses needs further research and a data platform. Therefore, herein we developed a database “HantavirusesDB (HVdb)”, where genomics, proteomics, immune resource, RNAi based therapeutics and information on the 3D structures of druggable targets of the Orthohantaviruses are provided on a single platform. The database allows the researchers to effectively map the therapeutic strategies by designing multi-epitopes subunit vaccine and RNA based therapeutics. Moreover, the ease of the web interface allow the users to retrieve specific information from the database. Because of the high quality and excellent functionality of the HVdb, therapeutic research of Hantaviruses can be accelerated, and data analysis might be a foundation to design better treatment strategies targeting the hantaviruses. The database is accessible at http://hvdb.dqweilab-sjtu.com/index.php.

汉坦病毒是人类几种严重呼吸道疾病的病原体，据报道它们会在人与人之间传播。为了应对任何潜在的大流行，这组病毒需要进一步的研究和数据平台。因此，在此我们开发了一个数据库“HantavirusesDB (HVdb)”，其中在单个平台上提供基因组学、蛋白质组学、免疫资源、基于 RNAi 的疗法和关于 Orthohantaviruses 可药物靶点的 3D 结构的信息。该数据库允许研究人员通过设计多表位亚单位疫苗和基于 RNA 的疗法来有效地绘制治疗策略。此外，Web 界面的易用性允许用户从数据库中检索特定信息。由于 HVdb 的高质量和出色的功能，可以加速汉坦病毒的治疗研究，数据分析可能是设计更好的针对汉坦病毒的治疗策略的基础。该数据库可通过 http://hvdb.dqweilab-sjtu.com/index.php 访问。