Background. Statins reportedly have anti-inflammatory effects aside from their lipid-lowering impact. We investigated the effects of statin therapy on the level of C-reactive protein (CRP) or highly sensitive CRP (hs-CRP), a liver-derived marker of systemic inflammation, among stroke patients. Methods. An online search was performed in Scopus, PubMed/MEDLINE, ISI Web of Science, and Google Scholar up to November 2020 to recognize clinical trials investigating the effects of statins on the CRP level in stroke patients. Results. Overall, nine studies (11 treatment arms) with 1659 participants met the inclusion criteria. Six out of 9 studies (8 out of 11 arms) were categorized as studies with a high-quality methodological approach using the Cochrane Collaboration’s tool. Data from 5 treatment arms indicated a significant decrease in CRP concentration, and in one treatment arm, CRP concentration did not suggest any considerable alteration following statin therapy. Moreover, two treatment arms showed a significant reduction in hs-CRP concentration and three treatment arms revealed no significant alteration in hs-CRP concentration following statin therapy. Generally, results were heterogeneous and independent of the type of statin, statin dose, treatment duration, and changes in plasma low-density lipoprotein cholesterol concentration. Conclusion. The results suggest that statin therapy could reduce and, therefore, could be considered in these patients as potential anti-inflammatory agents.

中文翻译：

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他汀类药物对中风患者 C 反应蛋白的影响：临床试验的系统评价

背景。据报道，他汀类药物除了具有降脂作用外，还具有抗炎作用。我们调查了他汀类药物治疗对中风患者 C 反应蛋白 (CRP) 或高度敏感 CRP (hs-CRP) 水平的影响，后者是肝脏衍生的全身炎症标志物。方法。截至 2020 年 11 月，在 Scopus、PubMed/MEDLINE、ISI Web of Science 和 Google Scholar 中进行了在线搜索，以识别调查他汀类药物对中风患者 CRP 水平影响的临床试验。结果. 总体而言，有 1659 名参与者的 9 项研究（11 个治疗组）符合纳入标准。9 项研究中有 6 项（11 组中的 8 项）被归类为使用 Cochrane 协作工具的高质量方法学方法的研究。来自 5 个治疗组的数据表明 CRP 浓度显着降低，在一个治疗组中，CRP 浓度未表明他汀类药物治疗后有任何显着变化。此外，两个治疗组显示 hs-CRP 浓度显着降低，三个治疗组显示他汀类药物治疗后 hs-CRP 浓度没有显着变化。一般来说，结果是异质的，并且与他汀类药物的类型、他汀类药物剂量、治疗持续时间和血浆低密度脂蛋白胆固醇浓度的变化无关。结论. 结果表明，他汀类药物治疗可以减少，因此可以考虑在这些患者中作为潜在的抗炎药。