Evaluation of the Carbon Nanostructures Toxicity as a Function of Their Dimensionality Using Model Organisms: a Review,Water, Air, & Soil Pollution

当前位置： X-MOL 学术 › Water Air Soil Pollut. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Evaluation of the Carbon Nanostructures Toxicity as a Function of Their Dimensionality Using Model Organisms: a Review
Water, Air, & Soil Pollution ( IF 3.8 ) Pub Date : 2021-08-29 , DOI: 10.1007/s11270-021-05326-6
Paulo Castro Cardoso da Rosa ₁ , Mayara Bitencourt Leão ₁ , Carolina Ferreira de Matos ₁ , Cristiane Lenz Dalla Corte ₂

Affiliation

Nanotechnology has been widely used, with nanomaterials being applied in several technologies. However, little is known about the real toxicological risk that can be caused by nanomaterials. These materials can be divided according to their dimensionalities. The current classification schemes for nanostructured materials are based on these dimensionalities, generally as zero (0D), one (1D), two (2D), and three dimensions (3D). Toxicological studies to present broad and consistent information on nanomaterials toxicity mechanisms, in vitro and in vivo studies in several experimental models are necessary. Thus, this short review presents the toxicological potential of carbon nanomaterials, divided by their dimensionality, in the main in vitro and in vivo experimental models, especially alternative models. As a result, it was possible to observe that the toxicity of carbon nanomaterials does not vary according to the dimensionality of 0D, 1D, and 2D materials. For these materials, it is not possible to infer a direct relationship between dimensionality and toxicity. However, recent studies have shown that three-dimensional graphene species tend to have less toxicity than materials with a smaller number of dimensions. Finally, it was possible to note the importance of using several experimental models, especially alternative models, in order to increase the understanding of toxicity mechanisms of carbon nanomaterials.

Graphical Abstract

中文翻译：

使用模型生物评估碳纳米结构的毒性作为其维度的函数：综述

纳米技术已被广泛应用，纳米材料被应用于多种技术。然而，人们对纳米材料可能引起的真正毒理学风险知之甚少。这些材料可以根据它们的维度进行划分。当前纳米结构材料的分类方案基于这些维度，通常为零 (0D)、一 (1D)、二 (2D) 和三维 (3D)。毒理学研究提供关于纳米材料毒性机制的广泛和一致的信息，在几个实验模型中进行体外和体内研究是必要的。因此，这篇简短的评论介绍了碳纳米材料在主要体外和体内实验模型，尤其是替代模型中的毒理学潜力，按维度划分。其结果，可以观察到碳纳米材料的毒性不随 0D、1D 和 2D 材料的维数而变化。对于这些材料，无法推断维度和毒性之间的直接关系。然而，最近的研究表明，三维石墨烯物种往往比具有较少维度的材料具有更低的毒性。最后，可以注意到使用几种实验模型，特别是替代模型的重要性，以增加对碳纳米材料毒性机制的理解。最近的研究表明，三维石墨烯物种的毒性往往比维数较少的材料要小。最后，可以注意到使用几种实验模型，特别是替代模型的重要性，以增加对碳纳米材料毒性机制的理解。最近的研究表明，三维石墨烯物种的毒性往往比维数较少的材料要小。最后，可以注意到使用几种实验模型，特别是替代模型的重要性，以增加对碳纳米材料毒性机制的理解。

图形概要

更新日期：2021-08-29

点击分享查看原文

点击收藏

阅读更多本刊最新论文