BACKGROUND Sarcopenia has been proved to be related to the prognosis of patients with bladder cancer (BC) after radical cystectomy (RC). The relationship between sarcopenia and the occurrence of venous thromboembolism (VTE) after RC is unclear. METHODS We collected data of 252 BC patients treated with RC at our institution. Data was obtained from the electronic medical record database. Sarcopenia was defined by the third lumbar vertebra skeletal muscle index (SMI) which was measured using preoperative computed tomography. The primary outcome was the incidence of VTE within 30 days after the surgery in sarcopenia and non-sarcopenia groups. Outcomes between the two cohorts were compared using univariate analysis. Multivariate logistic regression was used to control for differences between cohorts. RESULTS Two hundred fifty-two patients were enrolled, of which 85 (33.7%) patients were in sarcopenia group, while 167 (66.3%) patients were not in sarcopenia group. The incidence of total VTE in sarcopenia group was higher than that in the extended group (10.6% vs. 1.8%, p = 0.005). Sarcopenia did not cause an increase in other postoperation 30 days complications (all p > 0.05). Multivariate analysis confirmed sarcopenia was independently associated with increased odds of VTE (OR = 4.18, 95% CI [1.01-17.27]; p = 0.048). Subgroup analysis showed that patients with VTE tended to be older (76.5 vs 66.0, p = 0.025) and have higher proportion of diabetes (58.3% vs 14.2%, p < 0.001) as well as lower level of serum albumin (35.0 g/L vs 40.4 g/L, p = 0.023) compared with those without VTE. CONCLUSIONS Sarcopenia was an independent predictor for VTE with patients undergoing RC for BC.

中文翻译：

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肌肉减少症作为膀胱癌根治性膀胱切除术患者静脉血栓栓塞事件的独立预测因子。

背景已证实少肌症与膀胱癌（BC）患者根治性膀胱切除术（RC）后的预后有关。RC 后肌肉减少症与静脉血栓栓塞 (VTE) 发生之间的关系尚不清楚。方法 我们收集了在我们机构接受 RC 治疗的 252 名 BC 患者的数据。数据来自电子病历数据库。肌肉减少症的定义是使用术前计算机断层扫描测量的第三腰椎骨骼肌指数 (SMI)。主要结果是肌肉减少症组和非肌肉减少症组手术后 30 天内 VTE 的发生率。使用单变量分析比较两个队列之间的结果。多变量逻辑回归用于控制队列之间的差异。结果共纳入252例患者，其中少肌症组85例（33.7%），非少肌症组167例（66.3%）。少肌症组总 VTE 的发生率高于扩展组（10.6% vs. 1.8%，p = 0.005）。肌肉减少症并未导致其他术后 30 天并发症增加（所有 p > 0.05）。多变量分析证实，肌肉减少症与 VTE 几率增加独立相关（OR = 4.18, 95% CI [1.01-17.27]；p = 0.048）。亚组分析显示，VTE 患者年龄较大（76.5 vs 66.0，p = 0.025），糖尿病比例较高（58.3% vs 14.2%，p < 0.001）以及血清白蛋白水平较低（35.0 g/L vs 40.4 g/L，p = 0.023）与没有 VTE 的相比。