Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes,Allergy

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Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes
Allergy ( IF 12.6 ) Pub Date : 2021-08-28 , DOI: 10.1111/all.15066
Pia Gattinger ₁ , Katarzyna Niespodziana ₁ , Karin Stiasny ₂ , Sabina Sahanic ₃ , Inna Tulaeva _{1,

4} , Kristina Borochova ₁ , Yulia Dorofeeva ₁ , Thomas Schlederer ₁ , Thomas Sonnweber ₃ , Gerhard Hofer ₅ , Renata Kiss ₆ , Bernhard Kratzer ₇ , Doris Trapin ₇ , Peter A Tauber ₇ , Arno Rottal ₇ , Ulrike Körmöczi ₇ , Melanie Feichter ₇ , Milena Weber ₁ , Margarete Focke-Tejkl _{1,

8} , Judith Löffler-Ragg ₃ , Bernhard Mühl ₉ , Anna Kropfmüller ₁₀ , Walter Keller ₁₁ , Frank Stolz ₆ , Rainer Henning ₆ , Ivan Tancevski ₃ , Elisabeth Puchhammer-Stöckl ₂ , Winfried F Pickl _{7,

8} , Rudolf Valenta _{1,

4,

8,

12}

Affiliation

Department of Pathophysiology and Allergy Research, Division of Immunopathology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Center for Virology, Medical University of Vienna, Vienna, Austria.
Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Laboratory for Immunopathology, Department of Clinical Immunology and Allergology, Sechenov First Moscow State Medical University, Moscow, Russia.
Department of Materials and Environmental Chemistry, University of Stockholm, Stockholm, Sweden.
Viravaxx AG, Vienna, Austria.
Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Karl Landsteiner University of Health Sciences, Krems, Austria.
Labors.at, Vienna, Austria.
Österreichische Gesundheitskasse, Klinikum Peterhof, Baden, Austria.
Institute of Molecular Biosciences, BioTechMed Graz, University of Graz, Graz, Austria.
NRC Institute of Immunology, FMBA, Moscow, Russia.

The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. As novel variants emerge, understanding their likelihood of suppression by population antibody repertoires has become increasingly important.

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