The existing evidence on the relationships of serum zinc, copper, and zinc/copper ratio with sleep duration is limited and conflicting. The present cross-sectional study aimed to investigate these associations in general adults by utilizing data from the 2011–2016 National Health and Nutrition Examination Survey. The concentrations of zinc and copper were measured in serum samples. Sleep duration (self-reported usual sleep duration) was categorized as < 7 h/night (short sleep duration), 7–8 h/night (optimal sleep duration), and > 8 h/night (long sleep duration). Multinomial logistic regression models and restricted cubic splines were constructed to examine the associations of serum zinc, copper, and zinc/copper ratio with sleep duration. A total of 5067 adults were included. After multivariate adjustment, compared with the optimal sleep duration group, the odds ratios (ORs) (95% confidence intervals, CIs) in the long sleep duration group for the highest versus lowest quartile of serum zinc concentration and zinc/copper ratio were 0.61 (0.39–0.96) and 0.58 (0.38–0.89), respectively. Furthermore, among males, the OR (95% CI) of long sleep duration for the highest versus lowest quartile of serum copper concentration was 2.23 (1.15–4.32). Finally, the dose–response trends suggested that participants with optimal sleep duration had the highest serum zinc concentration and zinc/copper ratio and a slightly lower serum copper concentration. No significant association was found between serum zinc, copper concentrations and the zinc/copper ratio and short sleep duration. In conclusion, serum zinc and zinc/copper ratio were inversely related to long sleep duration in adults, while serum copper was positively associated with long sleep duration in males.

关于血清锌、铜和锌/铜比与睡眠时间的关系的现有证据有限且相互矛盾。目前的横断面研究旨在利用 2011-2016 年全国健康和营养检查调查的数据调查一般成年人的这些关联。测量血清样品中锌和铜的浓度。睡眠时间（自我报告的正常睡眠时间）分为< 7 小时/晚（睡眠时间短）、7-8 小时/晚（最佳睡眠时间）和> 8 小时/晚（睡眠时间长）。构建了多项逻辑回归模型和限制三次样条，以检查血清锌、铜和锌/铜比率与睡眠时间的关系。共纳入 5067 名成年人。多元调整后，与最佳睡眠时间组相比，长睡眠时间组血清锌浓度和锌/铜比值最高和最低四分位数的比值比 (ORs) (95% CIs) 为 0.61 (0.39–0.96)和 0.58 (0.38–0.89)，分别。此外，在男性中，血清铜浓度最高与最低四分位数的长睡眠时间的 OR (95% CI) 为 2.23 (1.15–4.32)。最后，剂量反应趋势表明，睡眠时间最佳的参与者血清锌浓度和锌/铜比最高，血清铜浓度略低。血清锌、铜浓度与锌/铜比和短睡眠时间之间没有发现显着关联。综上所述，