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Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.
Archives of Virology ( IF 2.7 ) Pub Date : 2021-08-27 , DOI: 10.1007/s00705-021-05208-6 Abril Paulina Rodríguez-Maldonado 1 , Joel Armando Vázquez-Pérez 2 , Alberto Cedro-Tanda 3 , Blanca Taboada 4 , Celia Boukadida 5 , Claudia Wong-Arámbula 1 , Tatiana Ernestina Nuñez-García 1 , Natividad Cruz-Ortiz 1 , Gisela Barrera-Badillo 1 , Lucía Hernández-Rivas 1 , Irma López-Martínez 1 , Alfredo Mendoza-Vargas 3 , Juan Pablo Reyes-Grajeda 3 , Nicolas Alcaraz 3 , Fernando Peñaloza-Figueroa 3 , Dulibeth Gonzalez-Barrera 3 , Daniel Rangel-DeLeon 3 , Luis Alonso Herrera-Montalvo 3 , Fidencio Mejía-Nepomuceno 2 , Alejandra Hernández-Terán 2 , Mario Mújica-Sánchez 2 , Eduardo Becerril-Vargas 2 , José Arturo Martínez-Orozco 2 , Rogelio Pérez-Padilla 2 , Jorge Salas-Hernández 2 , Alejandro Sanchez-Flores 4 , Pavel Isa 4 , Margarita Matías-Florentino 5 , Santiago Ávila-Ríos 5 , José Esteban Muñoz-Medina 6 , Concepción Grajales-Muñiz 6 , Angel Gustavo Salas-Lais 6 , Andrea Santos Coy-Arechavaleta 6 , Alfredo Hidalgo-Miranda 3 , Carlos F Arias 5 , José Ernesto Ramírez-González 1
Archives of Virology ( IF 2.7 ) Pub Date : 2021-08-27 , DOI: 10.1007/s00705-021-05208-6 Abril Paulina Rodríguez-Maldonado 1 , Joel Armando Vázquez-Pérez 2 , Alberto Cedro-Tanda 3 , Blanca Taboada 4 , Celia Boukadida 5 , Claudia Wong-Arámbula 1 , Tatiana Ernestina Nuñez-García 1 , Natividad Cruz-Ortiz 1 , Gisela Barrera-Badillo 1 , Lucía Hernández-Rivas 1 , Irma López-Martínez 1 , Alfredo Mendoza-Vargas 3 , Juan Pablo Reyes-Grajeda 3 , Nicolas Alcaraz 3 , Fernando Peñaloza-Figueroa 3 , Dulibeth Gonzalez-Barrera 3 , Daniel Rangel-DeLeon 3 , Luis Alonso Herrera-Montalvo 3 , Fidencio Mejía-Nepomuceno 2 , Alejandra Hernández-Terán 2 , Mario Mújica-Sánchez 2 , Eduardo Becerril-Vargas 2 , José Arturo Martínez-Orozco 2 , Rogelio Pérez-Padilla 2 , Jorge Salas-Hernández 2 , Alejandro Sanchez-Flores 4 , Pavel Isa 4 , Margarita Matías-Florentino 5 , Santiago Ávila-Ríos 5 , José Esteban Muñoz-Medina 6 , Concepción Grajales-Muñiz 6 , Angel Gustavo Salas-Lais 6 , Andrea Santos Coy-Arechavaleta 6 , Alfredo Hidalgo-Miranda 3 , Carlos F Arias 5 , José Ernesto Ramírez-González 1
Affiliation
SARS-CoV-2 variants emerged in late 2020, and at least three variants of concern (B.1.1.7, B.1.351, and P1) have been reported by WHO. These variants have several substitutions in the spike protein that affect receptor binding; they exhibit increased transmissibility and may be associated with reduced vaccine effectiveness. In the present work, we report the identification of a potential variant of interest, harboring the mutations T478K, P681H, and T732A in the spike protein, within the newly named lineage B.1.1.519, that rapidly outcompeted the preexisting variants in Mexico and has been the dominant virus in the country during the first trimester of 2021.
中文翻译：
主要存在于墨西哥的 SARS-CoV-2 的潜在感兴趣变体 (VOI) B.1.1.519 的出现和传播。
SARS-CoV-2 变体于 2020 年末出现，世卫组织报告了至少三个值得关注的变体（B.1.1.7、B.1.351 和 P1）。这些变体在刺突蛋白中有几个影响受体结合的替换。它们表现出更高的传播性，并可能与疫苗效力降低有关。在目前的工作中，我们报告了在新命名的 B.1.1.519 谱系中发现了一种潜在的感兴趣变体，在刺突蛋白中含有突变 T478K、P681H 和 T732A，它迅速超过了墨西哥和在 2021 年头三个月期间，该病毒一直是该国的主要病毒。
更新日期：2021-08-27
中文翻译：
主要存在于墨西哥的 SARS-CoV-2 的潜在感兴趣变体 (VOI) B.1.1.519 的出现和传播。
SARS-CoV-2 变体于 2020 年末出现，世卫组织报告了至少三个值得关注的变体（B.1.1.7、B.1.351 和 P1）。这些变体在刺突蛋白中有几个影响受体结合的替换。它们表现出更高的传播性，并可能与疫苗效力降低有关。在目前的工作中，我们报告了在新命名的 B.1.1.519 谱系中发现了一种潜在的感兴趣变体，在刺突蛋白中含有突变 T478K、P681H 和 T732A，它迅速超过了墨西哥和在 2021 年头三个月期间，该病毒一直是该国的主要病毒。
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