The cAMP responsive element modulator (CREM) is a transcriptional regulator of different effector cytokines in CD4+ T cells including IL-2, IL-17, IL-21 but also IL-4 and IL-13 and thus an important determinant of central T helper cell functions. Our review gives an overview over the regulation of CREM in T cells and the pleiotropic effects of CREM on CD4+ T cells in health and autoimmune diseases with a particular focus on systemic lupus erythematosus.

中文翻译：

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cAMP 反应元件调节剂 (CREM) 是 CD4+ T 细胞功能的调节剂


cAMP 反应元件调节剂 (CREM) 是 CD4+ T 细胞中不同效应细胞因子的转录调节因子，包括 IL-2、IL-17、IL-21、IL-4 和 IL-13，因此是中枢 T 辅助细胞的重要决定因素细胞功能。我们的综述概述了 T 细胞中 CREM 的调节以及 CREM 对健康和自身免疫性疾病中 CD4+ T 细胞的多效作用，特别关注系统性红斑狼疮。