Blue rubber bleb naevus syndrome (BRBNS) is a rare disease that usually presents with multiple venous malformations in the skin and gastrointestinal tract. Lesions located in the gastrointestinal tract always result in chronic gastrointestinal bleeding and severe anemia. The successful management of BRBNS with sirolimus had been reported in many institutions, due to its impact on signaling pathways of angiogenesis. However, the experience in treatment of neonates with BRBNS was limited.

中文翻译：

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西罗莫司治疗新生儿蓝色橡皮泡痣综合征一例。

蓝色橡胶泡痣综合征 (BRBNS) 是一种罕见的疾病，通常表现为皮肤和胃肠道多发静脉畸形。位于胃肠道的病变总是导致慢性胃肠道出血和严重贫血。由于西罗莫司对血管生成信号通路的影响，许多机构已经报道了使用西罗莫司成功治疗 BRBNS。然而，BRBNS 治疗新生儿的经验有限。