Hepatocellular carcinoma (HCC) is a malignant tumor that occurs in the liver. Its onset is latent, and it shows high heterogeneity and can readily experience intrahepatic metastasis or systemic metastasis, which seriously affects patients' quality of life. Numerous studies have shown that hypoxia inducible factor1α (HIF-1α) plays a significant role in the occurrence and development of tumors, as it promotes the formation of intratumoral vessels and plays a key role in their metastasis and invasion. Some studies have reported that caspase-3, which is induced by various factors, is involved in the apoptosis of tumor cells.

中文翻译：

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caspase-3和缺氧诱导因子1α在肝细胞癌合并出血坏死中的表达[J].

肝细胞癌（HCC）是一种发生在肝脏的恶性肿瘤。其起病隐匿，异质性高，易发生肝内转移或全身转移，严重影响患者的生活质量。大量研究表明，缺氧诱导因子1α（HIF-1α）在肿瘤的发生和发展中起着重要作用，因为它促进了瘤内血管的形成，在肿瘤的转移和侵袭中起关键作用。有研究报道，多种因素诱导的caspase-3参与了肿瘤细胞的凋亡。