Nonalcoholic fatty pancreas disease (NAFPD) is an emerging disease that has gained an increasing amount of attention in recent years. It describes fat accumulation in the pancreas with insignificant alcohol consumption, but the pathogenesis is largely unknown. A wide range of terms have been used to describe the phenomenon of pancreatic fat accumulation, but NAFPD remains an under-recognized and non-independent disorder. Obesity, age, sex, race, and unhealthy lifestyle are established independent risk factors for NAFPD, which is strongly associated with metabolic syndrome, type 2 diabetes, pancreatitis, pancreatic fistula, pancreatic cancer, and nonalcoholic fatty liver disease. At present, imaging techniques are common diagnostic aids, but uniform criteria and consensus are lacking. Therapeutically, healthy diet, weight loss, and exercise are the mainstays to reduce pancreatic fat accumulation. It can be seen that there is a limited understanding of NAFPD at this stage and further exploration is needed. Previous studies have revealed that NAFPD may directly affect diagnosis and clinical decision-making. Therefore, exploring the pathophysiological mechanism and clinical associations of NAFPD is a major challenge for researchers and clinicians.

中文翻译：

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非酒精性脂肪性胰腺疾病：新出现的临床挑战。

非酒精性脂肪性胰腺疾病 (NAFPD) 是一种新兴疾病，近年来受到越来越多的关注。它描述了少量饮酒后胰腺中的脂肪堆积，但其发病机制在很大程度上是未知的。已经使用了多种术语来描述胰腺脂肪堆积的现象，但 NAFPD 仍然是一种未被充分认识和非独立的疾病。肥胖、年龄、性别、种族和不健康的生活方式是 NAFPD 的独立危险因素，与代谢综合征、2 型糖尿病、胰腺炎、胰瘘、胰腺癌和非酒精性脂肪肝密切相关。目前，影像技术是常见的诊断辅助手段，但缺乏统一的标准和共识。治疗上，健康饮食，减肥，运动是减少胰腺脂肪堆积的主要方式。可见现阶段对NAFPD的认识有限，需要进一步探索。先前的研究表明，NAFPD 可能直接影响诊断和临床决策。因此，探索 NAFPD 的病理生理机制和临床关联是研究人员和临床医生面临的重大挑战。