Cervical spondylosis is a disease that occurs with age and affects the discs and joints in the cervical spine located in the neck. The hydroxyapatite (HA) bone graft substitutes can used as a potential bone-forming agent, however, the efficacy of using HA is challenging in cervical reconstruction. In this regard, nano-based HA was used in this study to explore its sagittal parameters and clinical potency in relative to titanium (TiO₂) cage in patient with cervical spondylosis. 50 patients suffering from cervical spondylosis were divided in two groups and were grafted with either TiO₂ cage or nano-HA. The sagittal parameters, including cervical spine lateral radiographs (C_0-2Coob and C_2-7Coob) were taken pre- and post-operation (3-month, one-year and two-year). The clinical potency was also done based on the JOA scores. Angle analysis indicated that the C_0-2Cobb and C_2-7Cobb angles were significantly changed after the operation in both TiO₂ cage and nano-HA groups, whereas no significant changes was determined in nano-HA relative to TiO₂ cage condition. Also, it was shown that JOA scores were significantly higher after the operation than pre-operation, indicating a potential cervical reconstruction after surgery in both groups which slightly were higher for nano-HA groups.

中文翻译：

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钛笼与纳米羟基磷灰石骨移植替代物在宫颈重建中的比较。

颈椎病是一种随着年龄的增长而发生的疾病，会影响位于颈部的颈椎椎间盘和关节。羟基磷灰石 (HA) 骨移植替代物可用作潜在的骨形成剂，然而，使用 HA 的功效在宫颈重建中具有挑战性。在这方面，本研究中使用纳米 HA 来探索其相对于钛 (TiO2) 笼在颈椎病患者中的矢状参数和临床效力。50 名颈椎病患者分为两组，分别移植 TiO2 笼或纳米 HA。矢状面参数，包括颈椎侧位片（C _0-2 Coob 和 C _2-7Coob) 在手术前和手术后 (3 个月、一年和两年) 进行。临床效力也基于 JOA 评分进行。角度分析表明，TiO 2 笼和nano-HA 组的C _0-2 Cobb 和C _2-7 Cobb 角在操作后发生了显着变化，而nano-HA 相对于TiO2 笼条件没有显着变化。此外，还显示手术后的 JOA 评分显着高于手术前，表明两组手术后都有潜在的颈椎重建，纳米 HA 组略高。