Titanium (Ti) and its alloys are widely used in bone surgery by virtue of their excellent mechanical properties and good biocompatibility; however, complications such as loosening and sinking have been reported post-implantation. Herein we deposited a copper-cobalt (Cu-Co) co-doped titanium dioxide (TUO) coating on the surface of Ti implants by microarc oxidation. The osteogenic and antimicrobial properties of the coating were evaluated by in vitro experiments, and we also assessed β-catenin expression levels on different sample surfaces. Our results revealed that the coating promoted the adhesion, proliferation, and differentiation of MG63 osteoblasts, and TUO coating promoted β-catenin expression; moreover, the proliferation of Staphylococcus aureus was inhibited. To summarize, we report that Cu-Co co-doping can enhance the osteogenic and antibacterial activities of orthopedic Ti implants, leading to potentially improved clinical performance.

中文翻译：

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具有成骨和抗菌特性的钛上的 Cu-Co 共掺杂微孔涂层。

钛（Ti）及其合金以其优异的力学性能和良好的生物相容性被广泛应用于骨外科；然而，据报道植入后会出现松动和下沉等并发症。在这里，我们通过微弧氧化在 Ti 植入物的表面上沉积了铜钴 (Cu-Co) 共掺杂二氧化钛 (TUO) 涂层。通过体外实验评估了涂层的成骨和抗菌性能，我们还评估了不同样品表面的β-连环蛋白表达水平。我们的结果表明，涂​​层促进了MG63成骨细胞的粘附、增殖和分化，而TUO涂层促进了β-连环蛋白的表达；此外，扩散金黄色葡萄球菌被抑制。总而言之，我们报告说，Cu-Co 共掺杂可以增强骨科钛植入物的成骨和抗菌活性，从而可能改善临床性能。