Cell migration is an essential process that controls many physiological functions ranging from development to immunity. In vivo, cells are guided by a combination of physical and chemical cues. Chemokines have been the center of attention for years, but the role of physical properties of tissues has been under-investigated, despite the fact that these properties can be drastically modified in pathology. Here, we discuss the role of one important tissue physical property, hydraulic resistance, in cell guidance, a phenomenon referred to as barotaxis, and describe the underlying physical principles and molecular mechanisms. Finally, we speculate on the putative role of barotaxis in physiological processes involving immune and cancer cells.

中文翻译：

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Barotaxis：细胞如何在压力下生存和移动。

细胞迁移是控制从发育到免疫的许多生理功能的重要过程。在体内，细胞由物理和化学线索的组合引导。多年来，趋化因子一直是关注的焦点，但组织的物理特性的作用尚未得到充分研究，尽管这些特性可以在病理学中彻底改变。在这里，我们讨论了一个重要的组织物理特性，液压阻力，在细胞引导中的作用，这种现象被称为 barotaxis，并描述了潜在的物理原理和分子机制。最后，我们推测压力趋向性在涉及免疫和癌细胞的生理过程中的假定作用。