Synthesis and Properties of Oligonucleotides Containing 2′-O,4′-C-Ethylene-Bridged 5-Methyluridine with Exocyclic Methylene and Methyl Groups in the Bridge,European Journal of Organic Chemistry

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Synthesis and Properties of Oligonucleotides Containing 2′-O,4′-C-Ethylene-Bridged 5-Methyluridine with Exocyclic Methylene and Methyl Groups in the Bridge
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-08-26 , DOI: 10.1002/ejoc.202100947
Yuta Ito ₁ , Kodai Nishida ₁ , Norika Tsutsui ₁ , Yasufumi Fuchi ₁ , Yoshiyuki Hari ₁

Affiliation

Oligonucleotides containing 6′-methylene-ENA and 6′R-Me-ENA were synthesized and their properties (duplex-forming ability toward ssRNA and ssDNA, triplex-forming ability toward dsDNA, thermodynamic parameters, and enzymatic stability) were investigated. The thermal stabilities of 6′-methylene-ENA- and 6′R-Me-ENA-modified oligonucleotides when complexes with ssRNA and dsDNA under molecular crowding conditions were also examined.

中文翻译：

含2'-O,4'-C-亚乙基-桥接5-甲基尿苷的寡核苷酸的合成与性质，桥上带有环外亚甲基和甲基

含6'-亚甲基ENA和6'的寡核苷酸- [R -Me-ENA的合成和它们的属性（向的ssRNA和单链DNA，形成三链体的能力朝向的dsDNA，热力学参数，和酶稳定双链体形成的能力）进行了调查。6'-亚甲基ENA-和6'的热稳定性[R时也进行了检查分子聚集的条件下用的ssRNA和dsDNA复合体-Me-ENA-修饰的寡核苷酸。

更新日期：2021-09-17

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