Asymmetry of the insula-sensorimotor circuit in Parkinson's disease,European Journal of Neuroscience

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Asymmetry of the insula-sensorimotor circuit in Parkinson's disease
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-08-27 , DOI: 10.1111/ejn.15432
Gadi Goelman ₁ , Rotem Dan _{1,

2} , Filip Růžička ₃ , Ondrej Bezdicek ₃ , Robert Jech ₃

Affiliation

Patients with Parkinson's disease (PD) experience motor and non-motor symptoms, suggesting alterations of the motor and/or limbic system or more probably of their communications. We hypothesized that the communication between the insula (part of the limbic system) and sensorimotor cortex in PD is altered and hemispheric asymmetric. Furthermore, that this asymmetry relates to non-motor symptoms, and specifically, that apathy-related asymmetry is unique to PD. To test these hypotheses, we used a novel multivariate time-frequency analysis method applied to resting-state functional magnetic resonance imaging (MRI) data of 28 controls and 25 participants with PD measured in their OFF medication state. The analysis infers directionality of coupling, that is, afferent or efferent, among four anatomical regions, thus defining directed pathways of information flow, which enables the extension of symmetry measures to include directionality. A major right asymmetry reduction of the dorsal-posterior insula efferent and a slight bilateral increase of insula afferent pathways were observed in participants with PD versus controls. Between-group pathways that correlated with mild cognitive impairments combined the central-executive and default-mode networks through the right insula. Apathy-correlated pathways of the posterior insula in participants with PD versus controls exhibited reduced right efferent and increased left afferent. Because apathy scores were comparable between the groups and effects of the other motor and non-motor symptoms were statistically removed by the analysis, the differences in apathy-correlated pathways were suggested as unique to PD. These pathways could be predictors in the pre-symptomatic phase in patients with apathy.

中文翻译：

帕金森病中岛叶-感觉运动回路的不对称性

帕金森病 (PD) 患者会出现运动和非运动症状，这表明运动和/或边缘系统或更可能是他们的交流发生了改变。我们假设 PD 中脑岛（边缘系统的一部分）和感觉运动皮层之间的交流发生了改变，并且半球不对称。此外，这种不对称性与非运动症状有关，具体而言，与冷漠相关的不对称性是 PD 独有的。为了验证这些假设，我们使用了一种新的多变量时频分析方法，该方法适用于 28 名对照组和 25 名在药物治疗关闭状态下测量的 PD 参与者的静息状态功能磁共振成像 (MRI) 数据。分析推断耦合的方向性，即传入或传出，在四个解剖区域之间，因此定义了信息流的定向路径，这使得对称度量的扩展包括方向性。与对照组相比，在 PD 参与者中观察到背-后岛叶传出的右侧不对称性显着减少，岛叶传入通路的双侧略有增加。与轻度认知障碍相关的组间通路通过右脑岛结合了中央执行网络和默认模式网络。与对照组相比，PD 参与者后脑岛的冷漠相关通路表现出右传出减少和左传入增加。由于冷漠评分在各组之间具有可比性，并且其他运动和非运动症状的影响被分析从统计学上排除，因此冷漠相关通路的差异被认为是 PD 独有的。

更新日期：2021-09-21

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