Urea hydrogen peroxide-initiated synthesis of pyranopyrazoles through oxidative coupling under base- and metal-free conditions by physical grinding method,Molecular Diversity

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Urea hydrogen peroxide-initiated synthesis of pyranopyrazoles through oxidative coupling under base- and metal-free conditions by physical grinding method
Molecular Diversity ( IF 3.9 ) Pub Date : 2021-08-27 , DOI: 10.1007/s11030-021-10278-4
Pratibha Verma ₁ , Swati Chauhan ₁ , Vishal Singh ₁ , Sundaram Singh ₁ , Vandana Srivastava ₁

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A novel multicomponent one-pot expeditious synthesis of highly functionalized and pharmaceutically fascinated pyranopyrazoles has been developed. This reaction occurs via tandem Knoevenagel condensation reaction of methyl aryl derivatives, 3-methyl pyrazolone and malononitrile in the presence of urea hydrogen peroxide under the physical grinding method. The present methodology offers several benefits such as available green and cheap starting materials, solvent-free, mild reaction conditions, high atom economy, eco-friendly standards, excellent yields and easy isolation of the products without column chromatographic separation.

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中文翻译：

物理研磨法在无碱和无金属条件下氧化偶联尿素过氧化氢引发合成吡喃吡唑

已经开发出一种新型的多组分一锅法快速合成高度官能化和药学上令人着迷的吡喃吡唑。该反应通过甲基芳基衍生物、3-甲基吡唑啉酮和丙二腈的串联 Knoevenagel 缩合反应在过氧化脲存在下在物理研磨法下发生。本方法提供了许多好处，例如可用的绿色和廉价的起始材料、无溶剂、温和的反应条件、高原子经济性、环保标准、优异的收率和无需柱色谱分离即可轻松分离产品。

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更新日期：2021-08-27

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