Detection of anticancer drug (doxorubicin) using an electrochemical sensor is developed based on a transition metal vanadate’s related carbon composite material. With an environmentally friendly process, we have synthesized a metal oxide composite of iron vanadate nanoparticle assembled with sulfur-doped carbon nanofiber (FeV/SCNF). The FeV/SCNF composite was characterized using XRD, TEM, FESEM with elemental mapping, XPS and EDS. In contrast to other electrodes reported in the literature, a much-improved electrochemical efficiency is shown by FeV/SCNF composite modified electrodes. Amperometric technique has been employed at 0.25 V (vs. Ag/AgCl) for the sensitive detection of DOX within a wide range of 20 nM–542.5 μM and it possesses enhanced selectivity in presence of common interferents. The modified electrochemical sensors show high sensitivity of 46.041 μA μM⁻¹ cm⁻². The newly developed sensor could be used for the determination of doxorubicin in both blood serum and drug formulations with acceptable results, suggesting its feasibility for real-time applications.

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中文翻译：

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钒酸铁修饰的硫掺杂碳纳米纤维纳米复合材料的深共熔溶剂合成：阿霉素的电化学传感工具

基于过渡金属钒酸盐的相关碳复合材料开发了使用电化学传感器检测抗癌药物（阿霉素）。通过环保工艺，我们合成了钒酸铁纳米颗粒与硫掺杂碳纳米纤维（FeV/SCNF）组装的金属氧化物复合材料。使用 XRD、TEM、FESEM 和元素映射、XPS 和 EDS 对 FeV/SCNF 复合材料进行了表征。与文献中报道的其他电极相比，FeV/SCNF 复合修饰电极显示出显着提高的电化学效率。安培技术已在 0.25 V（相对于 Ag/AgCl）下用于在 20 nM–542.5 μM 的宽范围内灵敏检测 DOX，并且在常见干扰物存在下具有增强的选择性。^-1 厘米^-2。新开发的传感器可用于测定血清和药物制剂中的阿霉素，结果可接受，表明其在实时应用中的可行性。

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