Introduction: Mast cells and their major protein, the serine proteinase tryptase, can be involved in cutaneous photodamage and carcinogenesis. The serum test of tryptase (S-tryptase) measures total tryptase protein (active tryptase and inactive protryptases), and S-tryptase is elevated in a variety of diseases, for example, in mastocytosis and α-tryptasemia. Objectives: The objective of this study is to study whether S-tryptase is a marker of cutaneous photodamage and carcinogenesis. Methods: Adult subjects (n = 399, aged 21–79) evaluated to be at risk for skin cancers were recruited at the dermatological policlinic and examined for photodamage severity, mole count, actinic keratoses (AKs), skin cancers, and immunosuppression (IS). A blood sample was analyzed for S-tryptase using the ImmunoCAP® Tryptase fluoroenzymeimmunoassay. Results: There was no difference in S-tryptase between non-IS (n = 321) and IS (n = 78) subjects or between genders. S-tryptase correlated slightly to photodamage and AKs in 321 non-IS subjects, and this association can be related, in part, to the age of subjects. In 34 subjects, S-tryptase was elevated (≥13.5 ng/mL), and in 20 males, but not in 14 females, the photodamage level was significantly (p = 0.031) more severe than in 179 males with normal S-tryptase. In contrast, there were more frequently subjects (n = 12) with past or present skin cancer (basal or squamous cell carcinoma or melanoma) in 14 females with elevated S-tryptase than in 186 female controls. So far, no explanation has been found for the elevated S-tryptase. Conclusion: There are significant associations between elevated S-tryptase and skin carcinogenesis, but the molecular mechanisms are unclear and gender differences can exist.
Int Arch Allergy Immunol

中文翻译：

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升高的血清类胰蛋白酶与皮肤光损伤和皮肤癌的关联

简介：肥大细胞及其主要蛋白质丝氨酸蛋白酶类胰蛋白酶可参与皮肤光损伤和致癌作用。类胰蛋白酶（S-类胰蛋白酶）的血清测试测量总类胰蛋白酶蛋白（活性类胰蛋白酶和非活性类胰蛋白酶），S-类胰蛋白酶在多种疾病中升高，例如肥大细胞增多症和α-类胰蛋白酶。目的：本研究的目的是研究 S-类胰蛋白酶是否是皮肤光损伤和致癌作用的标志物。方法：成人受试者（ n= 399，年龄 21-79）被评估为有患皮肤癌风险的人在皮肤科诊所招募，并检查光损伤的严重程度、痣数量、光化性角化病 (AK)、皮肤癌和免疫抑制 (IS)。使用 ImmunoCAP® 类胰蛋白酶荧光酶免疫测定法分析血样中的 S-类胰蛋白酶。结果：非 IS ( n = 321) 和 IS ( n = 78) 受试者或性别之间的 S-类胰蛋白酶没有差异。S-类胰蛋白酶与 321 名非 IS 受试者的光损伤和 AK 略有相关，这种关联可能部分与受试者的年龄有关。在 34 名受试者中，S-类胰蛋白酶升高（≥13.5 ng/mL），并且在 20 名男性中，而不是在 14 名女性中，光损伤水平显着（p= 0.031) 比具有正常 S-类胰蛋白酶的 179 名男性更严重。相比之下，在 S-类胰蛋白酶升高的 14 名女性中，与 186 名女性对照相比，过去或现在患有皮肤癌（基底细胞癌或鳞状细胞癌或黑色素瘤）的受试者（n = 12）更频繁。到目前为止，还没有找到对升高的 S-类胰蛋白酶的解释。结论： S-类胰蛋白酶升高与皮肤癌变之间存在显着关联，但分子机制尚不清楚，可能存在性别差异。
Int Arch 过敏免疫