Abstract

Objectives

This study aims to evaluate the medium to long-term (1–12 years) effectiveness of two-duct ligation (2-DL) in patients with nonprogressive neurodisabilities.

Methods

Main outcomes included a Visual Analogue Scale (VAS), Drooling Severity (DS) and Drooling Frequency (DF), collected at baseline, 32 weeks postintervention and 1–12 years postintervention. Secondary outcomes were adverse events (AEs), and satisfaction.

Results

Forty-two patients were analyzed (mean age 17 years, mean baseline VAS 82). VAS decreased significantly from baseline to long-term (n = 30. Mean difference −36.5, CI -47.0 to −26.0, p ≤ 0.001; −26.1, CI -36.2 to −15.9, p ≤ 0.001). However, long-term VAS significantly increased compared to VAS at 32 weeks (+10.4, CI 1.0–19.8, p = 0.031). Out of 42 patients, 64% would recommend 2-DL to peers.

Conclusion

There is a significant subjective 2-DL effect on drooling severity in the medium to long-term as reported by patients and caregivers, but there is also a certain degree of recurrence in this time span, and 33% of the patients required subsequent treatment. However, the majority of patients and/or caregivers would recommend 2-DL to peers.

中文翻译：

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横断面研究双导管结扎对神经障碍患者过度流口水的中长期影响

摘要

目标

本研究旨在评估双管结扎术 (2-DL) 在非进行性神经障碍患者中的​​中长期（1-12 年）有效性。

方法

主要结果包括在基线、干预后 32 周和干预后 1-12 年收集的视觉模拟量表 (VAS)、流口水严重程度 (DS) 和流口水频率 (DF)。次要结果是不良事件 (AE) 和满意度。

结果

分析了 42 名患者（平均年龄 17 岁，平均基线 VAS 82）。VAS 从基线到长期显着降低（n = 30。平均差异 -36.5，CI -47.0 至 -26.0，p ≤ 0.001；-26.1，CI -36.2 至 -15.9，p ≤ 0.001）。然而，与 32 周时的 VAS 相比，长期 VAS 显着增加（+10.4，CI 1.0-19.8，p = 0.031）。在 42 名患者中，64% 会向同龄人推荐 2-DL。

结论

患者和护理人员报告的中长期流口水严重程度主观 2-DL 影响显着，但在此时间跨度内也有一定程度的复发，33% 的患者需要后续治疗。然而，大多数患者和/或护理人员会向同龄人推荐 2-DL。