The human body harbors a diverse microbiome that regulates host physiology and disease development. Several studies have also been reported where the human microbiome interferes with the efficacy of chemotherapeutics. Reports have also suggested the use of microbes in specific targeting and drug delivery. This review mainly focuses on the alteration in the efficacy of the drug by human microbiota. We have also discussed how the diversity in microbes can determine the therapeutic outcomes of a particular drug. The pathways involved in the alteration are also focused, with some highlights on microbes being used in cancer therapy.

中文翻译：

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微生物定义化疗药物的功效：一个完整​​的范例

人体拥有多种微生物组，可调节宿主生理机能和疾病发展。也有几项研究报告了人类微生物组干扰化疗药物的功效。报告还建议在特定靶向和药物递送中使用微生物。本综述主要关注人体微生物群对药物疗效的改变。我们还讨论了微生物的多样性如何决定特定药物的治疗效果。参与改变的途径也受到关注，其中一些重点是用于癌症治疗的微生物。