Gastric mucosa-associated lymphoid tissue non-Hodgkin lymphoma (gMALT NHL) is the second most common gastrointestinal lymphoma (50% of all gastric lymphomas), being closely associated with Helicobacter pylori infection, justifying that antibiotic therapy is effective in over 75% of all cases. This is a retrospective study analyzing all adult gMALT NHL cases diagnosed and treated in a single center for 8 years, focusing on demographic features, treatment outcomes, and survival analysis. Sixty patients with a median age of 61 years (53.3% female gender) were analyzed. Most of the cases had localized disease (66.7% were Lugano stage I) and had low IPI scores (median: 1). There was a high prevalence of Helicobacter pylori infection (68.3%). Nearly 97% of the cases received treatment for the disease, a median of one line; 55% of the patients treated endured complete response after first-line therapy (mostly antibiotics). Median overall survival time and median progression-free survival time were not reached. The mean follow-up time was 81.8 months (95% CI: [73.3–90.3]). Thirty-six patients (60%) achieved a 3-year follow-up time; the mortality rate was 15% at the end of the study. Age superior to 65 years and transformation into DLBCL were statistically significant negative prognostic markers for survival in this study (p = 0.006 and p = 0.033, respectively). Our study confirms that gMALT NHL is an indolent disease with long-term survival. Many patients, however, are exposed to several treatment lines along their disease course.

胃粘膜相关淋巴组织非霍奇金淋巴瘤 (gMALT NHL) 是第二常见的胃肠道淋巴瘤（占所有胃淋巴瘤的 50%），与幽门螺杆菌感染密切相关，证明抗生素治疗对超过 75% 的胃淋巴瘤  有效案例。这是一项回顾性研究，分析了 8 年来在单一中心诊断和治疗的所有成人 gMALT NHL 病例，重点关注人口特征、治疗结果和生存分析。对 60 名中位年龄为 61 岁的患者（53.3% 为女性）进行了分析。大多数病例患有局部疾病（66.7%为卢加诺I期）并且IPI评分较低（中位数：1）。幽门螺杆菌的患病率很高  感染（68.3%）。近97%的病例接受了该疾病的治疗，中位数为一线；55% 的接受治疗的患者在一线治疗（主要是抗生素）后获得完全缓解。未达到中位总生存时间和中位无进展生存时间。平均随访时间为 81.8 个月（95% CI：[73.3–90.3]）。36 名患者 (60%) 获得了 3 年的随访；研究结束时死亡率为 15%。在本研究中，年龄大于 65 岁和转化为 DLBCL 是统计上显着的生存负预后标志（p  = 0.006 和p = 0.033，分别）。我们的研究证实，gMALT NHL 是一种具有长期生存率的惰性疾病。然而，许多患者在其病程中会接受多种治疗。