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Bioinspired Conjugated Tri-Porphyrin-Based Intracellular pH-Sensitive Metallo-Supramolecular Nanoparticles for Near-Infrared Photoacoustic Imaging-Guided Chemo- and Photothermal Combined Therapy
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-08-26 , DOI: 10.1021/acsbiomaterials.1c00597 Zhe Zhang 1 , Weiwei Tang 1 , Yufeng Li 1 , Yue Cao 2 , Yuanhong Shang 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-08-26 , DOI: 10.1021/acsbiomaterials.1c00597 Zhe Zhang 1 , Weiwei Tang 1 , Yufeng Li 1 , Yue Cao 2 , Yuanhong Shang 1
Affiliation
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Porphyrins have been extensively used in clinical phototherapy. However, most of them exhibited absorption below 700 nm. We report conjugated tri-porphyrins showing absorption within a biological phototherapy window (700–850 nm). On this basis, bioinspired intracellular pH-sensitive metallo-supramolecular nanoparticles (NPs) are designed. They provide the simultaneous photothermal therapy and chemotherapy. After treatment by tail vein injection, the tumor was completely relieved without recurrence in a course of 27 days. These bioinspired intracellular pH-sensitive metallo-supramolecular NPs show excellent potential application in near-infrared photoacoustic imaging-guided chemo-photothermal combined therapy.
中文翻译：
用于近红外光声成像引导的化学和光热联合治疗的仿生共轭三卟啉细胞内 pH 敏感金属超分子纳米颗粒
卟啉已广泛用于临床光疗。然而，它们中的大多数表现出低于 700 nm 的吸收。我们报告了在生物光疗窗口（700-850 nm）内显示吸收的共轭三卟啉。在此基础上，设计了仿生细胞内 pH 敏感金属超分子纳米粒子 (NPs)。他们提供同步光热疗法和化学疗法。经尾静脉注射治疗，肿瘤完全缓解，27天疗程无复发。这些受生物启发的细胞内 pH 敏感金属超分子 NPs 在近红外光声成像引导的化学光热联合治疗中显示出极好的潜在应用。
更新日期：2021-09-13
中文翻译：
用于近红外光声成像引导的化学和光热联合治疗的仿生共轭三卟啉细胞内 pH 敏感金属超分子纳米颗粒
卟啉已广泛用于临床光疗。然而，它们中的大多数表现出低于 700 nm 的吸收。我们报告了在生物光疗窗口（700-850 nm）内显示吸收的共轭三卟啉。在此基础上，设计了仿生细胞内 pH 敏感金属超分子纳米粒子 (NPs)。他们提供同步光热疗法和化学疗法。经尾静脉注射治疗，肿瘤完全缓解，27天疗程无复发。这些受生物启发的细胞内 pH 敏感金属超分子 NPs 在近红外光声成像引导的化学光热联合治疗中显示出极好的潜在应用。
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