Water-Stable All-Inorganic Perovskite Nanocrystals with Nonlinear Optical Properties for Targeted Multiphoton Bioimaging,ACS Applied Nano Materials

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Water-Stable All-Inorganic Perovskite Nanocrystals with Nonlinear Optical Properties for Targeted Multiphoton Bioimaging
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2021-08-27 , DOI: 10.1021/acsanm.1c01621
Kok Ken Chan ₁ , David Giovanni ₂ , Huajun He ₂ , Tze Chien Sum ₂ , Ken-Tye Yong _{3,

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Affiliation

CsPbX₃ nanocrystals have been employed in various optoelectronic applications, such as light-emitting diodes and solar cells. Nevertheless, widespread application of CsPbX₃ nanocrystals has been largely restricted by their poor aqueous stability. Despite the tremendous efforts focused on encapsulating the CsPbX₃ nanocrystals, it is still very challenging to achieve CsPbX₃ nanocrystals with good aqueous stability. This work describes the preparation and encapsulation methods for CsPbBr₃/SiO₂/mPEG-DSPE nanocrystals that can be readily dispersed in water and biological buffers. To the best of our knowledge, this is the first work that reports multiphoton emissions from CsPbBr₃/SiO₂/mPEG-DSPE nanocrystals in water. The protection afforded by the silica shell and phospholipid micelles enables the CsPbBr₃/SiO₂/mPEG-DSPE nanocrystals in aqueous solution to exhibit enhanced long-term stability and better shielding against ultrasonication treatment and continuous light irradiation than bare CsPbBr₃ nanocrystals. The toxicity of the CsPbBr₃/SiO₂/mPEG-DSPE nanocrystals has been evaluated in various cell lines. Subsequently, the encapsulated nanocrystals were used for targeted single and multiphoton imaging of cancer cells. This work not only describes the preparation of water-stable CsPbBr₃ nanocrystals but also paves the way for their applications in multiphoton bioimaging applications.

中文翻译：

具有非线性光学特性的水稳定全无机钙钛矿纳米晶体用于靶向多光子生物成像

CsPb X ₃纳米晶体已用于各种光电应用，例如发光二极管和太阳能电池。然而，CsPb X ₃纳米晶体的广泛应用在很大程度上受到其较差的水性稳定性的限制。尽管在封装 CsPb X ₃纳米晶体方面付出了巨大的努力，但获得具有良好水稳定性的CsPb X ₃纳米晶体仍然非常具有挑战性。本工作描述了 CsPbBr ₃ /SiO ₂的制备和封装方法/mPEG-DSPE 纳米晶体，可以很容易地分散在水和生物缓冲液中。据我们所知，这是第一项报道水中 CsPbBr ₃ /SiO ₂ /mPEG-DSPE 纳米晶体的多光子发射的工作。二氧化硅壳和磷脂胶束提供的保护使水溶液中的 CsPbBr ₃ /SiO ₂ /mPEG-DSPE 纳米晶体表现出增强的长期稳定性和比裸 CsPbBr ₃纳米晶体更好地屏蔽超声波处理和连续光照射。CsPbBr ₃ /SiO ₂的毒性/mPEG-DSPE 纳米晶体已在各种细胞系中进行了评估。随后，封装的纳米晶体用于癌细胞的靶向单光子和多光子成像。这项工作不仅描述了水稳定性 CsPbBr ₃纳米晶体的制备，而且还为其在多光子生物成像应用中的应用铺平了道路。

更新日期：2021-09-24

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