Although large diameter vessels made of polyurethane materials have been widely used in clinical practice, the biocompatibility and long-term patency of small diameter artificial vessels have not been well addressed. Any technological innovation and advancement in small-diameter artificial blood vessels is of great interest to the biomedical field. Here a novel technique is used to produce artificial blood vessels with a caliber of less than 6 mm and a wall thickness of less than 0.5 mm by rotational exposure, and to form a bionic inner wall with a periodically micro-nano structure inside the tube by laser double-beam interference. The polyethylene glycol diacrylate used is a widely recognized versatile biomaterial with good hydrophilicity, biocompatibility and low cytotoxicity. The effect of the bionic structure on the growth of hepatocellular carcinoma cells and human umbilical vein endothelial cells was investigated, and it was demonstrated that the prepared vessels with the bionic structure could largely promote the endothelialization process of the cells inside them.

中文翻译：

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光聚合策略制备内壁微纳结构小直径人工血管


尽管聚氨酯材料制成的大直径血管已广泛应用于临床，但小直径人造血管的生物相容性和长期通畅性尚未得到很好的解决。小直径人造血管的任何技术创新和进步都会引起生物医学领域的极大兴趣。这里采用新技术，通过旋转曝光的方式制造出口径小于6毫米、壁厚小于0.5毫米的人造血管，并通过旋转曝光在管内形成周期性微纳结构的仿生内壁。激光双光束干涉。所用的聚乙二醇二丙烯酸酯是一种广泛认可的多功能生物材料，具有良好的亲水性、生物相容性和低细胞毒性。研究了该仿生结构对肝癌细胞和人脐静脉内皮细胞生长的影响，结果表明所制备的仿生结构血管能够很大程度上促进其内部细胞的内皮化过程。