Rapid large-area tissue imaging at the cellular resolution is important for clinical diagnosis. We present a probe-based confocal microendoscope (pCM) with a field-of-view (FOV) diameter over 500 μm, lateral resolution of 1.95 μm, and outer diameter of 2.6 mm, compatible with the biopsy channel of conventional gastroscopes. Compared to a conventional pCM, our system’s FOV increased by a factor of 4 while maintaining the probe size and cellular resolution—comparable to the FOV of Zeiss Axio Observer’s $20\times /0.8$ numerical aperture objective lens. Ex vivo imaging of wide areas in healthy and diseased rat gastrointestinal tract tissues demonstrates the system’s practicality.

中文翻译：

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用于胃肠道大面积可视化的 500 μm 视场探针共聚焦显微内窥镜

细胞分辨率的快速大面积组织成像对于临床诊断很重要。我们提出了一种基于探针的共聚焦显微内窥镜 (pCM)，其视野 (FOV) 直径超过 500 μm，横向分辨率为 1.95 μm，外径为 2.6 mm，与传统胃镜的活检通道兼容。与传统 pCM 相比，我们系统的 FOV 增加了 4 倍，同时保持了探头尺寸和细胞分辨率——与 Zeiss Axio Observer 的 FOV 相当$20\times /0.8$数值孔径物镜。健康和患病大鼠胃肠道组织大面积的离体成像证明了该系统的实用性。