Previously, we found a change in the efficiency of the modulatory action of ATP under the influence of some non-physiological factors at neuromuscular synapses in rodents. This study was aimed at evaluating the effect of ATP on synaptic transmission of isolated rat soleus muscles after denervation injury. It was shown that rats exhibited an increase in the strength of electrical stimulation-evoked contractions of the soleus muscles after 7-day denervation. Application of ATP increased the electrically evoked contractions of the intact soleus muscle but had no effect on the denervated muscle. The nonselective P2-receptor antagonist suramin abolished the effect of ATP. We speculate that the reduction of ATP activity in the rat model of denervation is most likely caused by a decrease in the number of P2-receptors on the nerve terminal because of impaired anterograde transport and decreased nerve fiber conduction velocity.

以前，我们发现在啮齿动物神经肌肉突触的一些非生理因素的影响下，ATP 的调节作用效率发生了变化。本研究旨在评估 ATP 对去神经损伤后离体大鼠比目鱼肌突触传递的影响。结果表明，大鼠在去神经支配 7 天后表现出电刺激诱发的比目鱼肌收缩的强度增加。ATP 的应用增加了完整比目鱼肌的电诱发收缩，但对去神经支配的肌肉没有影响。非选择性 P2 受体拮抗剂苏拉明消除了 ATP 的作用。