Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4-phenylene-bis [methylene])-bis (pyridine-3-carboxylicaicd): Synthesis, structural characterization, and antitumor activity,Applied Organometallic Chemistry

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Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4-phenylene-bis [methylene])-bis (pyridine-3-carboxylicaicd): Synthesis, structural characterization, and antitumor activity
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2021-08-26 , DOI: 10.1002/aoc.6427
Gongchi Liu ₁ , Shuangyan Wu ₁ , Wei Liu ₁ , Guoxu Gao ₁ , Ying Zhang ₁ , Enjun Gao ₂ , Mingchang Zhu _{1,

3}

Affiliation

In this work, three new complexes [Ln₂(L)₃·H₂O]_n (where Ln = Nd(1)、Eu (2) and Sm (3)) have been synthesized by H₂L (H₂L = 1,1 ‘(1,4-phenylene- bis [methylene])-bis (pyridine-3-carboxylicaicd)) and were characterized by X-ray single crystal diffraction and PXRD. The interaction of these complexes with FS DNA (fish sperm DNA) and the DNA binding constants of the complexes were determined using UV spectroscopy, indicating their ability to bind to FS DNA. The DNA binding constants k of the three complexes were 1.0186 × 10⁴, 5.047 × 10³, and 5.115 × 10³, respectively. The results of UV spectrum showed that the complex 1–3 was bound to DNA through hydrogen bonding. The interaction of the complexes with FS DNA was studied by fluorescence spectroscopy. The stern-volmer quenching values of complexes 1, 2, and 3 were 0.186, 0.093, and 0.114, respectively. Electrophoresis experiments showed that the three complexes could cleave DNA molecules. In addition, flow cytometry, and morphological apoptosis studies showed that the complex could induce apoptosis of HeLa tumor cells. Results all the three complexes had potential medicinal value.

中文翻译：

由 1,1'(1,4-亚苯基-双 [亚甲基])-双 (吡啶-3-羧酸) 桥接的三种新型螺旋链 Nd (III) Eu (III) Sm (III) 配合物：合成、结构表征、和抗肿瘤活性

在这项工作中，三个新的配合物[LN ₂（L）₃ ·H ₂ O] _Ñ（其中Ln =钕（1），铕（2）和Sm（3））已被由H合成₂ L（ħ ₂大号= 1,1'(1,4-亚苯基-双[亚甲基])-双(吡啶-3-羧酸))并通过X射线单晶衍射和PXRD表征。这些复合物与 FS DNA（鱼精子 DNA）的相互作用和复合物的 DNA 结合常数是使用紫外光谱测定的，表明它们与 FS DNA 结合的能力。三种复合物的 DNA 结合常数 k 分别为 1.0186 × 10 ⁴、5.047 × 10 ³和 5.115 × 10³、分别。紫外光谱结果表明配合物1-3通过氢键与DNA结合。通过荧光光谱研究了复合物与 FS DNA 的相互作用。配合物 1、2 和 3 的 stern-volmer 淬灭值分别为 0.186、0.093 和 0.114。电泳实验表明，这三种复合物都能切割DNA分子。此外，流式细胞术和形态学凋亡研究表明，该复合物可诱导 HeLa 肿瘤细胞凋亡。结果三种配合物均具有潜在的药用价值。

更新日期：2021-08-26

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