Microtubules (MT) have a role in the intracellular response to insulin stimulation and subsequent glucose transport by glucose transporter 4 (GLUT4), which resides in specialized storage vesicles that travel through the cell. Before GLUT4 is inserted into the plasma membrane for glucose transport, it undergoes complex trafficking through the cell via the integration of cytoskeletal networks. In this review, we highlight the importance of MT elements in insulin action in adipocytes through a summary of MT depolymerization studies, MT-based GLUT4 movement, molecular motor proteins involved in GLUT4 trafficking, as well as MT-related phenomena in response to insulin and links between insulin action and MT-associated proteins.

微管 (MT) 在细胞内对胰岛素刺激的反应和随后的葡萄糖转运蛋白 4 (GLUT4) 的葡萄糖转运中起作用，葡萄糖转运蛋白 4 (GLUT4) 存在于穿过细胞的专门储存囊泡中。在将 GLUT4 插入质膜进行葡萄糖转运之前，它会通过细胞骨架网络的整合通过细胞进行复杂的运输。在这篇综述中，我们通过总结 MT 解聚研究、基于 MT 的 GLUT4 运动、参与 GLUT4 运输的分子运动蛋白以及与胰岛素和 MT 相关的现象，强调了 MT 元件在脂肪细胞中胰岛素作用的重要性。胰岛素作用和 MT 相关蛋白之间的联系。