Lysosomal β-galactosylceramidase (GALC) removes β-galactose from β-galactosylceramide, thus generating the oncosuppressor metabolite ceramide. Recent observations have shown that GALC may exert opposite effects on tumor growth and differentiation, questioning its contribution to the sphingolipid metabolism in cancer cells and its role in tumor progression.

中文翻译：

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癌症中的β-半乳糖神经酰胺酶：朋友还是敌人？

溶酶体 β-半乳糖神经酰胺酶 (GALC) 从 β-半乳糖神经酰胺中去除 β-半乳糖，从而产生抑癌代谢物神经酰胺。最近的观察表明，GALC 可能对肿瘤的生长和分化产生相反的影响，质疑其对癌细胞鞘脂代谢的贡献及其在肿瘤进展中的作用。