Connexin-mediated intercellular communication mechanisms include bidirectional cell-to-cell coupling by gap junctions and release/influx of molecules by hemichannels. These intercellular communications have relevant roles in numerous immune system activities. Here, we review the current knowledge about the function of connexin channels, mainly those formed by connexin-43, on immunity and inflammation. Focusing on those evidence that support the design and development of therapeutic tools to modulate connexin expression and/or channel activities with treatment potential for infections, wounds, cancer, and other inflammatory conditions.

中文翻译：

---

免疫和炎症疾病病理生理学和治疗中的连接蛋白通道调节

连接蛋白介导的细胞间通讯机制包括通过间隙连接的双向细胞间偶联和半通道分子的释放/流入。这些细胞间通讯在许多免疫系统活动中具有相关作用。在这里，我们回顾了当前关于连接蛋白通道功能的知识，主要是由连接蛋白 43 形成的通道，对免疫和炎症的影响。关注那些支持设计和开发治疗工具以调节连接蛋白表达和/或通道活动的证据，这些证据具有治疗感染、伤口、癌症和其他炎症疾病的潜力。