There is a high incidence of cardiovascular disease in diabetes. Weight variability has been reported as independent risk factor for cardiovascular disease in the general population and preliminarily also in people with type 2 diabetes. Using data from the Swedish National Diabetes Register the possible link between visit-to-visit body weight variability and the risk of cardiovascular complications among people with type 2 diabetes and without prevalent cardiovascular diseases at baseline has been evaluated. Overall, 100,576 people with type 2 diabetes, with at least five measurements of body weight taken over three consecutive years, were included. Variability was expressed as quartiles of the standard deviation of the measures during the three years. The primary composite outcome included non-fatal myocardial infarction, non-fatal stroke, and all-cause mortality and was assessed during five years following the first 3 years of exposure to weight variability. After adjusting for known cardiovascular risk factors, the risk of the primary composite outcome significantly increased with increasing body weight variability [upper quartile HR = 1.45; 95% confidence interval 1.39–1.52]. Furthermore, elevated body weight variability was associated with almost all the other cardiovascular complications considered (non-fatal myocardial infarction, non-fatal stroke, all-cause mortality, peripheral arterial disease, peripheral vascular angioplasty, hospitalization for heart failure, foot ulcer, and all-cause mortality). High body weight variability predicts the development of cardiovascular complications in type 2 diabetes. These data suggest that any strategy to reduce the body weight in these subjects should be aimed at maintaining the reduction in the long-term, avoiding oscillations.

中文翻译：

---

2 型糖尿病中体重的变异性和心血管并发症的风险：瑞典国家糖尿病登记处的结果

糖尿病中心血管疾病的发病率很高。据报道，体重变异性是普通人群心血管疾病的独立危险因素，初步也适用于 2 型糖尿病患者。使用瑞典国家糖尿病登记处的数据，评估了基线时没有普遍心血管疾病的 2 型糖尿病患者的就诊体重变异性与心血管并发症风险之间的可能联系。总体而言，纳入了 100,576 名 2 型糖尿病患者，连续三年至少进行了五次体重测量。变异性表示为三年期间测量标准偏差的四分位数。主要复合结局包括非致死性心肌梗死、非致死性卒中、和全因死亡率，并在前 3 年暴露于体重变化后的 5 年内进行评估。在调整已知的心血管危险因素后，主要复合结局的风险随着体重变异性的增加而显着增加 [上四分位 HR = 1.45；95% 置信区间 1.39–1.52]。此外，体重变异性升高与几乎所有其他考虑的心血管并发症（非致命性心肌梗死、非致命性中风、全因死亡率、外周动脉疾病、外周血管成形术、心力衰竭住院、足部溃疡和全因死亡率）。高体重变异性可预测 2 型糖尿病心血管并发症的发展。