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The role of the odorant receptors in the formation of the sensory map
BMC Biology ( IF 5.4 ) Pub Date : 2021-08-27 , DOI: 10.1186/s12915-021-01116-y
Simona Francia 1, 2 , Claudia Lodovichi 2, 3, 4, 5
Affiliation  

In the olfactory system, odorant receptors (ORs) expressed at the cell membrane of olfactory sensory neurons detect odorants and direct sensory axons toward precise target locations in the brain, reflected in the presence of olfactory sensory maps. This dual role of ORs is corroborated by their subcellular expression both in cilia, where they bind odorants, and at axon terminals, a location suitable for axon guidance cues. Here, we provide an overview and discuss previous work on the role of ORs in establishing the topographic organization of the olfactory system and recent findings on the mechanisms of activation and function of axonal ORs.

中文翻译:

气味受体在感觉图形成中的作用

在嗅觉系统中,在嗅觉感觉神经元的细胞膜上表达的气味受体 (ORs) 检测气味并将感觉轴突导向大脑中的精确目标位置,这反映在嗅觉感觉图的存在上。ORs 的这种双重作用通过它们在纤毛中的亚细胞表达得到证实,它们在纤毛中结合气味,在轴突末端,一个适合轴突引导线索的位置。在这里,我们概述并讨论了以前关于 OR 在建立嗅觉系统拓扑组织中的作用的工作,以及最近关于轴突 OR 的激活和功能机制的发现。
更新日期:2021-08-27
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