Adeno-associated virus (AAV) is classified as a nonenveloped DNA virus. However, several years ago, we discovered that in media of packaging cells producing recombinant AAV vectors, AAV capsids can associate with the interior and surface of extracellular vesicles (EVs), sometimes referred to as exosomes. Since then, we and others have demonstrated that exosome-enveloped AAV, exo-AAV, can enhance transduction in vivo as well as evade neutralizing antibodies.

中文翻译：

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用纯化的细胞外囊泡包膜腺相关病毒载体中和抗体逃避和转导

腺相关病毒 (AAV) 被归类为无包膜 DNA 病毒。然而，几年前，我们发现在生产重组 AAV 载体的包装细胞培养基中，AAV 衣壳可以与细胞外囊泡 (EV)（有时称为外泌体）的内部和表面结合。从那时起，我们和其他人已经证明外泌体包裹的 AAV，exo-AAV，可以增强体内转导并逃避中和抗体。