High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D-25-Hydroxylase Expression and Serum 25-Hydroxyvitamin D3 Level through Elevating Circulating Cholesterol, Glucose, and Insulin Levels,Molecular Nutrition & Food Research

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High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D-25-Hydroxylase Expression and Serum 25-Hydroxyvitamin D3 Level through Elevating Circulating Cholesterol, Glucose, and Insulin Levels
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2021-08-27 , DOI: 10.1002/mnfr.202100220
Tengfei Zhu _{1,

2} , Jingyu Zhao ₁ , Shu Zhuo ₁ , Zhimin Hu ₁ , Shuyu Ouyang ₁ , Wunier ₁ , Shuting Yu ₁ , Yan Chen ₁ , Yu Li ₁ , Yingying Le _{1,

3}

Affiliation

Low circulating 25-hydroxyvitamin D (25(OH)D) levels associate with obesity, diabetes, and hyperlipidemia, but the underlying mechanisms remain uncertain. As energy-dense diet contributes to these disorders, this study investigates whether diet could impair vitamin D metabolism.

中文翻译：

高脂肪饮食和高胆固醇饮食通过提高循环胆固醇、葡萄糖和胰岛素水平来降低肝脏维生素 D-25-羟化酶表达和血清 25-羟基维生素 D3 水平

低循环 25-羟基维生素 D (25(OH)D) 水平与肥胖、糖尿病和高脂血症相关，但其潜在机制仍不确定。由于高能量饮食会导致这些疾病，本研究调查饮食是否会损害维生素 D 代谢。

更新日期：2021-11-04

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