Background

Inflammation is often related to cancer, and several inflammatory scores have been established to predict the prognosis of various types of cancer. Our study aimed to determine the prognostic value of the preoperative lymphocyte to C-reactive protein ratio (LCR) for predicting postoperative outcomes in patients with resectable gallbladder cancer (GBC).

Methods

A retrospective analysis of 104 GBC patients who received curative surgery at Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine from January 2000 to December 2016 was performed. A time-dependent receiver operating characteristic curve was constructed to evaluate the accuracy of different markers. Univariate and multivariate Cox proportional hazard models were used to define factors associated with overall survival.

Results

Among the assessed variables, the preoperative LCR showed the highest accuracy in predicting the overall survival of GBC patients (AUC: 0.736). Decreased preoperative LCR was significantly associated with advanced tumor stage, including tumor invasion (P = 0.018), lymph node metastasis (P = 0.011) and TNM stage (P = 0.022). A low preoperative LCR (cutoff threshold = 145.5) was an independent risk factor for overall survival in patients with resectable GBC (P < 0.001).

Conclusions

The preoperative LCR is a novel and valuable prognostic indicator of postoperative survival in patients with resectable GBC.

中文翻译：

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术前淋巴细胞与C反应蛋白比值作为可切除胆囊癌患者预后的新指标

背景

炎症通常与癌症有关，并且已经建立了几种炎症评分来预测各种癌症的预后。我们的研究旨在确定术前淋巴细胞与 C 反应蛋白比率 (LCR) 对预测可切除胆囊癌 (GBC) 患者术后结局的预后价值。

方法

回顾性分析2000年1月至2016年12月在上海交通大学医学院附属新华医院接受根治性手术的104例GBC患者。构建时间相关的接收者操作特征曲线来评估不同标记的准确性。单变量和多变量 Cox 比例风险模型用于定义与总生存期相关的因素。

结果

在评估的变量中，术前 LCR 在预测 GBC 患者的总生存率方面表现出最高的准确度（AUC：0.736）。术前LCR降低与肿瘤晚期分期显着相关，包括肿瘤浸润（P  =0.018）、淋巴结转移（P  =0.011）和TNM分期（P  =0.022）。较低的术前 LCR（截止阈值 = 145.5）是可切除 GBC 患者总体生存的独立危险因素（P < 0.001）。

结论

术前 LCR 是可切除 GBC 患者术后生存率的一种新颖且有价值的预后指标。