Lewis Acid Enables Ketone Phosphorylation to Form a C–P Bond and a C–C Bond: Synthesis of 9-Phosphoryl Fluorene Derivatives,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Lewis Acid Enables Ketone Phosphorylation to Form a C–P Bond and a C–C Bond: Synthesis of 9-Phosphoryl Fluorene Derivatives
Organic Letters ( IF 4.9 ) Pub Date : 2021-08-26 , DOI: 10.1021/acs.orglett.1c02504
Xiao-Hong Wei ₁ , Chun-Yuan Bai ₁ , Ai-Jun Wang ₁ , Qiao-Liang Feng ₁ , Lian-Biao Zhao ₁ , Ping Zhang ₁ , Zhen-Hua Li ₁ , Qiong Su ₁ , Yan-Bin Wang ₁

Affiliation

An efficient method for the Lewis acid promotion of the synthesis 9-phosphoryl fluorenes has been reported. This method focuses on ketone phosphonylation to form a C–P bond and a C–C bond between diphenylmethanone and H-phosphinate esters, H-phosphites, and H-phosphine oxides via phospha-aldol elimination, in which a series of 9-phosphoryl fluorene derivatives were selectively obtained in moderate to excellent yields.

中文翻译：

路易斯酸使酮磷酸化形成 C-P 键和 C-C 键：9-磷酰基芴衍生物的合成

已报道了一种用于路易斯酸促进合成 9-磷酰基芴的有效方法。该方法侧重于酮膦酰化，通过磷醛醇消除在二苯甲酮和 H-次膦酸酯、H-亚磷酸酯和 H-氧化膦之间形成 C-P 键和 C-C 键，其中一系列 9-磷酰基以中等至极好的收率选择性地获得芴衍生物。

更新日期：2021-09-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11