Mismatch negativity (MMN) elicited by decrements in sound pressure level has been asserted as evidence for its dependence upon general deviance detection, while refuting the proposition that it is simply caused by modulating the intrinsic sensory response with different physical properties of sound. However, reports of intensity-decrement MMN are sparse compared with MMN to stimulus frequency or duration changes, and verifying the mechanisms that shape difference waveform morphology is essential for their responsible use as clinical biomarkers. In the present study, open-access EEG data from 40 healthy young adults recorded during an intensity-decrement oddball paradigm was analyzed to establish the effects of transitions between different level stimuli on the auditory evoked response. Standard stimuli were 80 dB and deviant stimuli were 70 dB. Event-related potentials were extracted from standards after standards (sS), deviants after standards (sD), and standards after deviants (dS). Mean amplitude across a recommended measurement window for MMN (125 to 225 ms) was calculated for each ERP waveform. This revealed statistically significant negative amplitude shift elicited by lower-intensity deviant stimuli, as expected, and an opposite direction, positive amplitude shift elicited by higher-intensity standard stimuli that followed lower-intensity deviants, relative to standard stimuli presented consecutively. These findings indicate that intensity-modulation of the auditory response influences cortical activity measured during the latency range of MMN. To what extent the hypothesized deviance detection mechanisms may also contribute is uncertain and remains to be elucidated.

由声压级降低引起的失配负性 (MMN) 已被断言为它依赖于一般偏差检测的证据，同时驳斥了它只是由声音的不同物理特性调制内在感官反应引起的命题。然而，与 MMN 相比，关于刺激频率或持续时间变化的强度递减 MMN 的报道很少，验证塑造差异波形形态的机制对于它们作为临床生物标志物的负责任使用至关重要。在本研究中，分析了在强度递减古怪范式期间记录的 40 名健康年轻人的开放式脑电图数据，以确定不同水平刺激之间的转换对听觉诱发反应的影响。标准刺激为 80 分贝，异常刺激为 70 分贝。从标准后的标准 (sS)、标准后的偏差 (sD) 和偏差后的标准 (dS) 中提取事件相关电位。针对每个 ERP 波形计算了 MMN 推荐测量窗口（125 到 225 ms）的平均幅度。这揭示了由低强度异常刺激引起的统计学上显着的负幅移，正如预期的那样，以及相反方向，相对于连续呈现的标准刺激，由跟随低强度异常刺激的高强度标准刺激引起的正幅移。这些发现表明，听觉反应的强度调制会影响在 MMN 潜伏期范围内测量的皮质活动。假设的偏差检测机制在多大程度上也可能做出贡献是不确定的，仍有待阐明。