We investigated the effect of area postrema lesions and selective vagotomy of afferent fibers on emetine-induced nausea in rats. We evaluated the acquisition of the conditioned taste avoidance (CTA) to 0.1% saccharin solution after conditioning with emetine dihydrochloride (5.54 mg/kg, i.p., 1% BW). The CTA was measured in three groups of rats: a bilateral subdiaphragmatic afferent vagotomy group, an area postrema lesion group, and a sham lesion group. The bilateral vagotomy and sham groups of rats showed acquisition of CTA within 2 days of the test date. Taste avoidance was never conditioned in the area postrema lesion group. These results indicate that the area postrema plays a crucial role in the induction of emetine-induced nausea.

我们研究了区域 postrema 损伤和传入纤维的选择性迷走神经切断术对大鼠依米丁引起的恶心的影响。我们评估了使用依米丁二盐酸盐（5.54 mg/kg，腹腔注射，1% BW）调理后对 0.1% 糖精溶液的条件性味觉回避 (CTA) 的获得。在三组大鼠中测量 CTA：双侧膈下传入迷走神经切断术组、区域后部病变组和假病变组。双侧迷走神经切断术和假手术组大鼠显示在测试日期的 2 天内获得 CTA。味觉回避从未在区域后部病变组中得到调节。这些结果表明后极区在诱导依米丁引起的恶心中起着至关重要的作用。