This research aimed to assess curcumin (CUR) effects on fenitrothion (FNT), a broad-spectrum organophosphate insecticide, −induced hepatorenal damage. Thirty adult male Wistar rats were allocated at random to five equal groups orally administered distilled water containing 1% carboxyl methylcellulose, corn oil (1 mL/rat), CUR (100 mg/kg b.wt.), FNT (5 mg/kg b.wt.), or CUR + FNT. CUR and FNT were dosed three times a week for two months. At the end of this trial, blood and tissue samples (liver and kidney) were subjected to molecular, biochemical, and histopathological assessments. The results revealed that CUR significantly diminished the FNT-induced up-regulation of hepatic CYP1A1 and CYP1A2 transcriptional levels. Moreover, CUR significantly suppressed the increment of the serum levels of hepatic alanine aminotransferase, gamma-glutamyl transferase, and kidney damage indicators (urea and creatinine) in FNT-intoxicated rats. Furthermore, in the hepatic and renal tissues, CUR remarkably restored the FNT-associated depletion of the antioxidant enzymes (glutathione peroxidase, glutathione reductase, glutathione S transferase, catalase, and superoxide dismutase). In addition, CUR notably reduced the FNT-induced increment in malondialdehyde content in the hepatic and renal tissues. Besides, the pathological aberrations in liver and kidney tissues resulting from FNT exposure were significantly abolished in FNT + CUR treated rats. Overall, CUR could be an effective ameliorative agent against negative pesticide impacts like FNT.

本研究旨在评估姜黄素 (CUR) 对杀螟硫磷 (FNT)（一种广谱有机磷杀虫剂）引起的肝肾损伤的影响。将 30 只成年雄性 Wistar 大鼠随机分配到五个相等的组，口服含有 1% 羧甲基纤维素、玉米油 (1 mL/大鼠)、CUR (100 mg/kg b.wt.)、FNT (5 mg/kg b.wt.)，或 CUR + FNT。CUR 和 FNT 每周给药 3 次，持续两个月。在该试验结束时，对血液和组织样本（肝脏和肾脏）进行分子、生化和组织病理学评估。结果表明，CUR 显着减少了 FNT 诱导的肝脏 CYP1A1 和 CYP1A2 转录水平的上调。此外，CUR 显着抑制了血清肝丙氨酸转氨酶水平的升高，FNT 中毒大鼠的 γ-谷氨酰转移酶和肾损伤指标（尿素和肌酐）。此外，在肝和肾组织中，CUR 显着恢复了 FNT 相关的抗氧化酶（谷胱甘肽过氧化物酶、谷胱甘肽还原酶、谷胱甘肽 S 转移酶、过氧化氢酶和超氧化物歧化酶）的消耗。此外，CUR 显着降低了 FNT 诱导的肝和肾组织中丙二醛含量的增加。此外，FNT + CUR 处理的大鼠中，FNT 暴露导致的肝肾组织病理畸变显着消失。总体而言，CUR 可能是一种有效的改善剂，可以对抗 FNT 等农药的负面影响。CUR 显着恢复了 FNT 相关的抗氧化酶（谷胱甘肽过氧化物酶、谷胱甘肽还原酶、谷胱甘肽 S 转移酶、过氧化氢酶和超氧化物歧化酶）的消耗。此外，CUR 显着降低了 FNT 诱导的肝和肾组织中丙二醛含量的增加。此外，FNT + CUR 处理的大鼠中，FNT 暴露导致的肝肾组织病理畸变显着消失。总体而言，CUR 可能是一种有效的改善剂，可以对抗 FNT 等农药的负面影响。CUR 显着恢复了 FNT 相关的抗氧化酶（谷胱甘肽过氧化物酶、谷胱甘肽还原酶、谷胱甘肽 S 转移酶、过氧化氢酶和超氧化物歧化酶）的消耗。此外，CUR 显着降低了 FNT 诱导的肝和肾组织中丙二醛含量的增加。此外，FNT + CUR 处理的大鼠中，FNT 暴露导致的肝肾组织病理畸变显着消失。总体而言，CUR 可能是一种有效的改善剂，可以对抗 FNT 等农药的负面影响。在 FNT + CUR 治疗的大鼠中，FNT 暴露导致的肝肾组织病理畸变显着消失。总体而言，CUR 可能是一种有效的改善剂，可以对抗 FNT 等农药的负面影响。在 FNT + CUR 治疗的大鼠中，FNT 暴露导致的肝肾组织病理畸变显着消失。总体而言，CUR 可能是一种有效的改善剂，可以对抗 FNT 等农药的负面影响。