当前位置：
X-MOL 学术
›
J. Vector Borne Dis.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Molecular diagnosis and clinico-hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected dogs of Mizoram, India
Journal of Vector Borne Diseases ( IF 0.8 ) Pub Date : 2020-07-01 , DOI: 10.4103/0972-9062.311775 Chamniugongliu Gonmei 1 , Kalyan Sarma 1 , Parimal Roychoudhury 2 , M Ayub Ali 3 , Damodar Singh 4 , H Prasad 1 , F A Ahmed 5 , Rebecca Lalmuanpuii 1 , Nirali Shah 1 , Ningthoujam Suraj Singh 1 , Jitendra Kumar Choudhury 6
Journal of Vector Borne Diseases ( IF 0.8 ) Pub Date : 2020-07-01 , DOI: 10.4103/0972-9062.311775 Chamniugongliu Gonmei 1 , Kalyan Sarma 1 , Parimal Roychoudhury 2 , M Ayub Ali 3 , Damodar Singh 4 , H Prasad 1 , F A Ahmed 5 , Rebecca Lalmuanpuii 1 , Nirali Shah 1 , Ningthoujam Suraj Singh 1 , Jitendra Kumar Choudhury 6
Affiliation
Background & objectives: Babesiosis is a tick transmitted disease, infecting a wide variety of wild and domestic animals, as well as humans. This study was designed to investigate molecular diagnosis and clinic-hemato-biochemical and oxidant/antioxidant status in dogs of Mizoram, India.
Methods: A total 1200 dogs screened for babesiosis during 2017–18 and 53 dogs suspected for babesiosis by clinical signs and were confirmed by molecular diagnosis. Clinical signs were recorded; also blood samples were taken to investigate hematologic changes, serum biochemical variations and oxidative stress biomarkers.
Results: The overall incidence of babesiosis in dogs of Aizawl, Mizoram, India during the study period recorded was 1.25% (15/1200) and 28.3% cases confirmed from 53 suspected dogs (15/53). The most commonly observed clinical signs were fever, emaciation, depression and icterus and lymphadenopathy. Significant reduction in PCV, HB, RBCs, MCHC, total protein, and albumin along with significant increase in MCV, WBCs, monocytes and BUN were the most consistent hemato-biochemical changes. Oxidant/antioxidant assessment showed significant reduction in superoxide dismutase, catalase and total anti-oxidant (TAC) along with significant increase in lipid peroxidase (LPO) activities.
Interpretation & conclusion: The findings of this study demonstrated that the main causative agent of babesiosis in dogs in Mizoram Province is Babesia gibsoni which caused significant alteration of hemato-biochemical and oxidant-antioxidant status in dogs.
中文翻译：
印度米佐拉姆邦巴贝虫感染犬的分子诊断和临床血液生化改变和氧化抗氧化生物标志物
背景与目的：巴贝斯虫病是一种蜱传播疾病，可感染多种野生和家养动物以及人类。本研究旨在调查印度米佐拉姆邦犬的分子诊断和临床血液生化和氧化/抗氧化状态。
方法： 2017-18 年共筛查巴贝斯虫病犬 1200 只，通过临床症状疑似巴贝斯虫病并经分子诊断确诊的犬 53 只。记录临床症状；还采集了血液样本以研究血液学变化、血清生化变化和氧化应激生物标志物。
结果：研究期间记录的印度米佐拉姆邦 Aizawl 犬巴贝斯虫病的总体发病率为 1.25% (15/1200)，53 只疑似犬 (15/53) 确诊的病例为 28.3%。最常见的临床症状是发热、消瘦、抑郁、黄疸和淋巴结肿大。PCV、HB、RBC、MCHC、总蛋白和白蛋白的显着降低以及 MCV、WBC、单核细胞和 BUN 的显着增加是最一致的血液生化变化。氧化剂/抗氧化剂评估显示超氧化物歧化酶、过氧化氢酶和总抗氧化剂 (TAC) 显着减少，同时脂质过氧化物酶 (LPO) 活性显着增加。
解释与结论：本研究结果表明，米佐拉姆省犬巴贝斯虫病的主要病原体是Babesia gibsoni导致狗的血液生化和氧化抗氧化状态发生显着改变。
更新日期：2020-07-01
Methods: A total 1200 dogs screened for babesiosis during 2017–18 and 53 dogs suspected for babesiosis by clinical signs and were confirmed by molecular diagnosis. Clinical signs were recorded; also blood samples were taken to investigate hematologic changes, serum biochemical variations and oxidative stress biomarkers.
Results: The overall incidence of babesiosis in dogs of Aizawl, Mizoram, India during the study period recorded was 1.25% (15/1200) and 28.3% cases confirmed from 53 suspected dogs (15/53). The most commonly observed clinical signs were fever, emaciation, depression and icterus and lymphadenopathy. Significant reduction in PCV, HB, RBCs, MCHC, total protein, and albumin along with significant increase in MCV, WBCs, monocytes and BUN were the most consistent hemato-biochemical changes. Oxidant/antioxidant assessment showed significant reduction in superoxide dismutase, catalase and total anti-oxidant (TAC) along with significant increase in lipid peroxidase (LPO) activities.
Interpretation & conclusion: The findings of this study demonstrated that the main causative agent of babesiosis in dogs in Mizoram Province is Babesia gibsoni which caused significant alteration of hemato-biochemical and oxidant-antioxidant status in dogs.
中文翻译：
印度米佐拉姆邦巴贝虫感染犬的分子诊断和临床血液生化改变和氧化抗氧化生物标志物
背景与目的：巴贝斯虫病是一种蜱传播疾病，可感染多种野生和家养动物以及人类。本研究旨在调查印度米佐拉姆邦犬的分子诊断和临床血液生化和氧化/抗氧化状态。
方法： 2017-18 年共筛查巴贝斯虫病犬 1200 只，通过临床症状疑似巴贝斯虫病并经分子诊断确诊的犬 53 只。记录临床症状；还采集了血液样本以研究血液学变化、血清生化变化和氧化应激生物标志物。
结果：研究期间记录的印度米佐拉姆邦 Aizawl 犬巴贝斯虫病的总体发病率为 1.25% (15/1200)，53 只疑似犬 (15/53) 确诊的病例为 28.3%。最常见的临床症状是发热、消瘦、抑郁、黄疸和淋巴结肿大。PCV、HB、RBC、MCHC、总蛋白和白蛋白的显着降低以及 MCV、WBC、单核细胞和 BUN 的显着增加是最一致的血液生化变化。氧化剂/抗氧化剂评估显示超氧化物歧化酶、过氧化氢酶和总抗氧化剂 (TAC) 显着减少，同时脂质过氧化物酶 (LPO) 活性显着增加。
解释与结论：本研究结果表明，米佐拉姆省犬巴贝斯虫病的主要病原体是Babesia gibsoni导致狗的血液生化和氧化抗氧化状态发生显着改变。
京公网安备 11010802027423号